Integrase strand transfer inhibitor-associated diabetes mellitus: A case report

Peter S. Fong; Devon M. Flynn; Christopher D. Evans; P. Todd Korthuis

doi:10.1177/0956462416675107

Integrase strand transfer inhibitor-associated diabetes mellitus: A case report

Peter S. Fong, Devon M. Flynn, Christopher D. Evans, P. Todd Korthuis

Department of Medicine

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

Integrase strand transfer inhibitors (INSTIs) have become integral antiretroviral therapy (ART) agents for treating HIV infection. We report the case of a 44-year-old male with a history of hemophilia A who developed diabetes mellitus four months after switching from abacavir, lamivudine, and efavirenz to abacavir, lamivudine, and raltegravir. Hemoglobin A1C normalized without further need for exogenous insulin after raltegravir was switched back to efavirenz. In this case report, we will review a possible mechanism for INSTI-induced hyperglycemia and/or diabetes mellitus.

Original language	English (US)
Pages (from-to)	626-628
Number of pages	3
Journal	International Journal of STD and AIDS
Volume	28
Issue number	6
DOIs	https://doi.org/10.1177/0956462416675107
State	Published - May 1 2017

Keywords

HIV
Integrase inhibitors
diabetes mellitus
raltegravir

ASJC Scopus subject areas

Dermatology
Public Health, Environmental and Occupational Health
Pharmacology (medical)
Infectious Diseases

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10.1177/0956462416675107

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abstract = "Integrase strand transfer inhibitors (INSTIs) have become integral antiretroviral therapy (ART) agents for treating HIV infection. We report the case of a 44-year-old male with a history of hemophilia A who developed diabetes mellitus four months after switching from abacavir, lamivudine, and efavirenz to abacavir, lamivudine, and raltegravir. Hemoglobin A1C normalized without further need for exogenous insulin after raltegravir was switched back to efavirenz. In this case report, we will review a possible mechanism for INSTI-induced hyperglycemia and/or diabetes mellitus.",

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AU - Flynn, Devon M.

AU - Evans, Christopher D.

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AB - Integrase strand transfer inhibitors (INSTIs) have become integral antiretroviral therapy (ART) agents for treating HIV infection. We report the case of a 44-year-old male with a history of hemophilia A who developed diabetes mellitus four months after switching from abacavir, lamivudine, and efavirenz to abacavir, lamivudine, and raltegravir. Hemoglobin A1C normalized without further need for exogenous insulin after raltegravir was switched back to efavirenz. In this case report, we will review a possible mechanism for INSTI-induced hyperglycemia and/or diabetes mellitus.

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Integrase strand transfer inhibitor-associated diabetes mellitus: A case report

Abstract

Keywords

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