Intensity-based image registration by minimizing residual complexity

Andriy Myronenko, Xubo Song

Research output: Contribution to journalArticlepeer-review

280 Scopus citations


Accurate definition of the similarity measure is a key component in image registration. Most commonly used intensity-based similarity measures rely on the assumptions of independence and stationarity of the intensities from pixel to pixel. Such measures cannot capture the complex interactions among the pixel intensities, and often result in less satisfactory registration performances, especially in the presence of spatially-varying intensity distortions. We propose a novel similarity measure that accounts for intensity nonstationarities and complex spatially-varying intensity distortions in mono-modal settings. We derive the similarity measure by analytically solving for the intensity correction field and its adaptive regularization. The final measure can be interpreted as one that favors a registration with minimum compression complexity of the residual image between the two registered images. One of the key advantages of the new similarity measure is its simplicity in terms of both computational complexity and implementation. This measure produces accurate registration results on both artificial and real-world problems that we have tested, and outperforms other state-of-the-art similarity measures in these cases.

Original languageEnglish (US)
Article number5487419
Pages (from-to)1882-1891
Number of pages10
JournalIEEE Transactions on Medical Imaging
Issue number11
StatePublished - Nov 2010


  • Bias field
  • image registration
  • nonstationary intensity distortion
  • residual complexity
  • sparseness

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering


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