Interaction of Thymidylate Synthase with Pyridoxal 5′-Phosphate As Studied by UV/Visible Difference Spectroscopy and Molecular Modeling

Chemical Compounds

• Pyridoxal 87%
• Molecular Modeling 67%
• Ultraviolet Spectrum 60%
• Spectroscopy 47%
• Thiohemiacetal 30%
• Phosphate 11%
• dTMP 8%
• Aldehyde 7%
• Lysine Residue 6%
• Cysteine Residue 6%
• Amino-Acid Residue 5%
• Thiol 4%
• Schiff Base 4%
• Nucleotide 4%
• Reaction Stoichiometry 4%
• Titration 4%
• Kd 4%
• Binding Site 4%
• UV/VIS Spectroscopy 3%
• Carbon Atom 2%
• Protein 2%
• Molecule 1%

Medicine & Life Sciences

• Pyridoxal Phosphate 100%
• Thymidylate Synthase 99%
• Spectrum Analysis 73%
• 2'-deoxyuridylic acid 15%
• Phosphates 12%
• Aldehydes 11%
• Catalytic Domain 8%
• Enzymes 7%
• Schiff Bases 6%
• Lactobacillus casei 6%
• Sulfhydryl Compounds 5%
• Carbon 4%
• Lysine 4%
• Cysteine 4%
• Nucleotides 3%
• Binding Sites 3%
• Amino Acids 3%
• Proteins 1%