TY - JOUR
T1 - Interactions between tumor cells and microenvironment in breast cancer
T2 - A new opportunity for targeted therapy
AU - Mitra, Shreya
AU - Stemke-Hale, Katherine
AU - Mills, Gordon B.
AU - Claerhout, Sofie
PY - 2012
Y1 - 2012
N2 - Breast cancer remains the leading cause of morbidity and secondleading cause of death in women. Despite efforts to uncover new targeted therapies, a vast number of women diedue to refractory or recurrent breast tumors. Most breast cancer studies have focused on the intrinsic characteristics of breast tumor cells, including altered growth, proliferation, and metabolism. However, emerging research suggests that the tumor microenvironment can substantially affect relapse rates and therapeutic responses. In this review, we discuss the interactions between the tumor and microenvironment in breast cancer, with regardto mutational profiles and altered metabolism that could serve as potential therapeutic targets. We also describe current technologies available to study these interactions.
AB - Breast cancer remains the leading cause of morbidity and secondleading cause of death in women. Despite efforts to uncover new targeted therapies, a vast number of women diedue to refractory or recurrent breast tumors. Most breast cancer studies have focused on the intrinsic characteristics of breast tumor cells, including altered growth, proliferation, and metabolism. However, emerging research suggests that the tumor microenvironment can substantially affect relapse rates and therapeutic responses. In this review, we discuss the interactions between the tumor and microenvironment in breast cancer, with regardto mutational profiles and altered metabolism that could serve as potential therapeutic targets. We also describe current technologies available to study these interactions.
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U2 - 10.1111/j.1349-7006.2011.02183.x
DO - 10.1111/j.1349-7006.2011.02183.x
M3 - Review article
C2 - 22151725
AN - SCOPUS:84859711066
SN - 1347-9032
VL - 103
SP - 400
EP - 407
JO - Cancer Science
JF - Cancer Science
IS - 3
ER -