Interuncal distance: Marker of aging and Alzheimer disease

J. Howieson, J. A. Kaye, L. Holm, Diane Howieson

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


PURPOSE: To evaluate the utility of a recently reported simple measure of brain atrophy on MR imaging, the interuncal distance (IUD). METHODS: Measurements of the IUD were made over a 12-month interval in 10 patients with probable early Alzheimer disease and in a comparison group of age-matched healthy control subjects. The measurements were made in both the transaxial and coronal planes. RESULTS: Significant group differences for the coronal measurement of IUD were found in both the absolute value of the measurement and the IUD corrected for head size. There was overlap in IUD between the disease and the control groups. These differences were not found for the transaxial IUD. Significant positive correlations of the IUD with Mini-Mental State Examination score and Clinical Dementia Rating Scale stage were observed. Over the age range tested, age was not significantly correlated with IUD in the sample. CONCLUSIONS: The interuncal distance (IUD) is not a useful screening measurement for Alzheimer disease.

Original languageEnglish (US)
Pages (from-to)647-650
Number of pages4
JournalAmerican Journal of Neuroradiology
Issue number3
StatePublished - 1993


  • Age and aging
  • Brain magnetic resonance
  • Brain measurements
  • Degenerative brain disease
  • Dementia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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