Pd-catalyzed aryl-enone cyclization of 1 leads to Heck-type non-reductive cyclization product 3 and reductive cyclization product 4. Conditions have been developed to selectively form either 3 or 4 (or more highly functionalized 10 vs 11 or 13 vs 14). The formation of non-reductive cyclization products (3, 11, 14) requires an unusual apparent trans β-H elimination - some mechanistic possibilities that are consistent with the data are proposed.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Sep 25 1995|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry