Abstract
Pd-catalyzed aryl-enone cyclization of 1 leads to Heck-type non-reductive cyclization product 3 and reductive cyclization product 4. Conditions have been developed to selectively form either 3 or 4 (or more highly functionalized 10 vs 11 or 13 vs 14). The formation of non-reductive cyclization products (3, 11, 14) requires an unusual apparent trans β-H elimination - some mechanistic possibilities that are consistent with the data are proposed.
Original language | English (US) |
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Pages (from-to) | 7047-7050 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 36 |
Issue number | 39 |
DOIs | |
State | Published - Sep 25 1995 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry