Intraoperative Optical Coherence Tomography to Guide Corneal Biopsy: A Case Report

Eleanor M. Schmidt, Hillary C. Stiefel, Donald C. Houghton, Winston D. Chamberlain

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Purpose: To report on a new application of intraoperative optical coherence tomography (OCT) as a real-time imaging tool to help guide corneal biopsy. Methods: Single case report. After the negative result of a corneal biopsy, we used intraoperative OCT during repeat biopsy to assist in depth and acquisition of an anterior stromal opacity suspected to be immunoglobulin deposits. Results: The use of intraoperative OCT is a novel tool, which assisted in successful identification and conservative biopsy of corneal immunoglobulin deposits. Conclusions: Intraoperative OCT is a novel tool that assists in the identification and location of corneal pathology for biopsy.

Original languageEnglish (US)
Pages (from-to)639-641
Number of pages3
Issue number5
StatePublished - May 1 2019


  • corneal biopsy
  • corneal deposits
  • intraoperative anterior segment optical coherence tomography
  • paraproteinemias

ASJC Scopus subject areas

  • Ophthalmology


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