Intratubular hemoglobin casts in hemolysis-associated acute kidney injury

Mazdak A. Khalighi, Kammi J. Henriksen, Anthony Chang, Shane M. Meehan

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Kidney injury is a complication of intravascular hemolysis associated with many forms of hemolytic disease. Reports of kidney biopsy findings in patients with hemolysis-related kidney injury have focused primarily on the accumulation of hemosiderin pigment within proximal tubular epithelial cells (hemosiderosis), a feature of chronic hemolysis. The nephrotoxic effects of hemoglobin include direct cytotoxicity to tubular cells, but hemoglobin also can precipitate in distal nephron segments, forming obstructive casts. We present a case of hemolysis-associated tubular injury, characterized by acute onset of intravascular hemolysis followed by acute kidney injury with acute tubular injury and abundant intratubular casts containing hemoglobin.

Original languageEnglish (US)
Pages (from-to)337-341
Number of pages5
JournalAmerican Journal of Kidney Diseases
Issue number2
StatePublished - Feb 1 2015


  • Acute kidney injury (AKI)
  • acute tubular
  • biopsy acute
  • casts intravascular
  • hemolysis renal
  • injury hemoglobin
  • tubular necrosis

ASJC Scopus subject areas

  • Nephrology


Dive into the research topics of 'Intratubular hemoglobin casts in hemolysis-associated acute kidney injury'. Together they form a unique fingerprint.

Cite this