Investigation on the Anticancer Activity of Symmetric and Unsymmetric Cyclic Sulfamides

Jaden Jungho Jun; Divya Duscharla; Ramesh Ummanni; Paul R. Hanson; Sanjay V. Malhotra

doi:10.1021/acsmedchemlett.0c00460

Investigation on the Anticancer Activity of Symmetric and Unsymmetric Cyclic Sulfamides

Jaden Jungho Jun, Divya Duscharla, Ramesh Ummanni, Paul R. Hanson, Sanjay V. Malhotra

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The sulfamide functional group has been extensively employed in organic synthesis to discover probes and drugs in various applications such as cancer, human immunodeficiency virus (HIV), virus, and diabetes. Herein, we describe the synthesis of 7-membered symmetric and unsymmetric sulfamide compounds and their biological evaluation through the National Cancer Institute (NCI) panel of 60 human tumor cell lines (NCI-60) and the mechanism of action study. The results of a study from the NCI-60 cell line exhibited that many synthesized cyclic sulfamide compounds inhibited breast cancer (MDA-MB-468). The mechanism of action study of a representative compound 18 showed the inhibition of proliferation and apoptosis in A549 lung cancer cells.

Original language	English (US)
Pages (from-to)	202-210
Number of pages	9
Journal	ACS Medicinal Chemistry Letters
Volume	12
Issue number	2
DOIs	https://doi.org/10.1021/acsmedchemlett.0c00460
State	Published - Feb 11 2021

Keywords

A549 lung cancer
Anticancer activity
Cyclic sulfamide
NCI-60 cell line

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1021/acsmedchemlett.0c00460

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abstract = "The sulfamide functional group has been extensively employed in organic synthesis to discover probes and drugs in various applications such as cancer, human immunodeficiency virus (HIV), virus, and diabetes. Herein, we describe the synthesis of 7-membered symmetric and unsymmetric sulfamide compounds and their biological evaluation through the National Cancer Institute (NCI) panel of 60 human tumor cell lines (NCI-60) and the mechanism of action study. The results of a study from the NCI-60 cell line exhibited that many synthesized cyclic sulfamide compounds inhibited breast cancer (MDA-MB-468). The mechanism of action study of a representative compound 18 showed the inhibition of proliferation and apoptosis in A549 lung cancer cells.",

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AU - Duscharla, Divya

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AU - Malhotra, Sanjay V.

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AB - The sulfamide functional group has been extensively employed in organic synthesis to discover probes and drugs in various applications such as cancer, human immunodeficiency virus (HIV), virus, and diabetes. Herein, we describe the synthesis of 7-membered symmetric and unsymmetric sulfamide compounds and their biological evaluation through the National Cancer Institute (NCI) panel of 60 human tumor cell lines (NCI-60) and the mechanism of action study. The results of a study from the NCI-60 cell line exhibited that many synthesized cyclic sulfamide compounds inhibited breast cancer (MDA-MB-468). The mechanism of action study of a representative compound 18 showed the inhibition of proliferation and apoptosis in A549 lung cancer cells.

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Investigation on the Anticancer Activity of Symmetric and Unsymmetric Cyclic Sulfamides

Abstract

Keywords

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