@article{17ce254d2d5e42bd8fdf085ed45f7e8f,
title = "Investigation on the Anticancer Activity of Symmetric and Unsymmetric Cyclic Sulfamides",
abstract = "The sulfamide functional group has been extensively employed in organic synthesis to discover probes and drugs in various applications such as cancer, human immunodeficiency virus (HIV), virus, and diabetes. Herein, we describe the synthesis of 7-membered symmetric and unsymmetric sulfamide compounds and their biological evaluation through the National Cancer Institute (NCI) panel of 60 human tumor cell lines (NCI-60) and the mechanism of action study. The results of a study from the NCI-60 cell line exhibited that many synthesized cyclic sulfamide compounds inhibited breast cancer (MDA-MB-468). The mechanism of action study of a representative compound 18 showed the inhibition of proliferation and apoptosis in A549 lung cancer cells.",
keywords = "A549 lung cancer, Anticancer activity, Cyclic sulfamide, NCI-60 cell line",
author = "Jun, {Jaden Jungho} and Divya Duscharla and Ramesh Ummanni and Hanson, {Paul R.} and Malhotra, {Sanjay V.}",
note = "Funding Information: This investigation was generously supported by partial funds provided by the Petroleum Research Fund (PRF-AC, administered by the ACS), the National Institutes of Health (National Institute of General Medical Sciences RO1-GM58103), and a minority supplement (RO1-GM58103-S1, MdSJ). The authors thank Justin Douglas and Sarah Neuenswander in the University of Kansas Nuclear Magnetic Resonance (NMR) Laboratory and Dr. Todd Williams for high-resolution mass spectrometry (HRMS) analysis. Support for the NMR instrumentation was provided by NIH shared instrumentation grants P20 GM103418, S10RR024664, and S10 OD016360 and National Science Foundation (NSF) academic research infrastructure grants 9512331, 9977422, and 0320648. We also acknowledge the IICT communication number IICT/Pubs./2020/370. Publisher Copyright: {\textcopyright} 2021 American Chemical Society.",
year = "2021",
month = feb,
day = "11",
doi = "10.1021/acsmedchemlett.0c00460",
language = "English (US)",
volume = "12",
pages = "202--210",
journal = "ACS Medicinal Chemistry Letters",
issn = "1948-5875",
publisher = "American Chemical Society",
number = "2",
}