Ion channels as targets for cancer therapy

Minghua Li, Zhi Gang Xiong

Research output: Contribution to journalReview articlepeer-review

80 Scopus citations


Cancer is a leading cause of death in the world. Conventional treatments have severe side effects and low survival rate. It is important to discover new targets and therapeutic strategies to improve the clinical outcomes of cancer patients. Ion channels are specialized membrane proteins that play important roles in various physiological processes. Recent studies have shown that abnormal expression and/or activity of a number of ion channels e.g. voltage-gated K+, Na+, Ca2+ channels, TRP channels, and epithelial Na+/degenerin family of ion channels, are involved in the growth/proliferation, migration and/or invasion of cancer cells. In this review, we summarize the present knowledge about the roles of different ion channels in the development of cancer.

Original languageEnglish (US)
Pages (from-to)156-166
Number of pages11
JournalInternational Journal of Physiology, Pathophysiology and Pharmacology
Issue number2
StatePublished - 2011
Externally publishedYes


  • And epithelial Na/degenerin family of ion channels
  • Cancer
  • Ion channels
  • TRP channels
  • Therapeutic targets
  • Voltage-gated K, Na, Ca channels

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Physiology
  • Physiology (medical)


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