TY - JOUR
T1 - Iron homeostasis
T2 - Recently identified proteins provide insight into novel control mechanisms
AU - Zhang, An Sheng
AU - Enns, Caroline A.
PY - 2009/1/9
Y1 - 2009/1/9
N2 - Iron is an essential nutrient required for a variety of biochemical processes. It is a vital component of the heme in hemoglobin, myoglobin, and cytochromes and is also an essential cofac-tor for non-heme enzymes such as ribonucleotide reductase, the limiting enzyme for DNA synthesis. When in excess, iron is toxic because it generates superoxide anions and hydroxyl radicals that react readily with biological molecules, including proteins, lipids, and DNA. As a result, humans possess elegant control mechanisms to maintain iron homeostasis by coordinately regulating iron absorption, iron recycling, and mobilization of stored iron. Disruption of these processes causes either iron-deficient anemia or iron overload disorders. In this minireview, we focus on the roles of recently identified proteins in the regulation of iron homeostasis.
AB - Iron is an essential nutrient required for a variety of biochemical processes. It is a vital component of the heme in hemoglobin, myoglobin, and cytochromes and is also an essential cofac-tor for non-heme enzymes such as ribonucleotide reductase, the limiting enzyme for DNA synthesis. When in excess, iron is toxic because it generates superoxide anions and hydroxyl radicals that react readily with biological molecules, including proteins, lipids, and DNA. As a result, humans possess elegant control mechanisms to maintain iron homeostasis by coordinately regulating iron absorption, iron recycling, and mobilization of stored iron. Disruption of these processes causes either iron-deficient anemia or iron overload disorders. In this minireview, we focus on the roles of recently identified proteins in the regulation of iron homeostasis.
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U2 - 10.1074/jbc.R800017200
DO - 10.1074/jbc.R800017200
M3 - Short survey
C2 - 18757363
AN - SCOPUS:59449109182
SN - 0021-9258
VL - 284
SP - 711
EP - 715
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 2
ER -