Is there a therapeutic role for blood brain barrier disruption?

E. A. Neuwelt, P. Frenkel

Research output: Contribution to journalEditorialpeer-review

16 Scopus citations


Reversible transient blood-brain barrier disruption appears to be reasonably simple to achieve and fairly safe. One can project exploitation of such a delivery technique not only to the use of cytoreductive drugs for neoplasms in the brain but also for enhanced delivery of antibiotics in central nervous system infections or enzymes in circumstances of inborn errors of metabolism.

Original languageEnglish (US)
Pages (from-to)137-139
Number of pages3
JournalAnnals of internal medicine
Issue number1 I
StatePublished - Jan 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine


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