Isaacs' Syndrome

E. Ensrud, A. A. Amato

Research output: Chapter in Book/Report/Conference proceedingChapter


Isaacs' syndrome is an unusual and rare neurological condition characterized by stiffness and spasms of the skeletal muscle. It is an autoimmune disorder with autoantibodies directed against the peripheral nerve voltage-gated potassium channels. This article reviews the clinical and laboratory features, pathogenesis, and treatment of Isaacs' syndrome.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Number of pages2
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
StatePublished - Jan 1 2014
Externally publishedYes


  • Autoantibodies
  • Autoimmune
  • Cramps
  • Fasciculations
  • Myokymia
  • Myotonia
  • Neuromyotonia
  • Paraneoplastic
  • Stiffness

ASJC Scopus subject areas

  • Medicine(all)


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