TY - JOUR
T1 - Isolation of a Second Nonallelic Insulin-Like Growth Factor I Gene from the Salmon Genome
AU - Kavsan, Vadim M.
AU - Grebenjuk, Vladislav A.
AU - Koval, Anatoly P.
AU - Skorokhod, Alexander S.
AU - Roberts, Charles T.
AU - Leroith, Derek
PY - 1994/5
Y1 - 1994/5
N2 - We have characterized a second nonallelic insulin-like growth factor-I (IGF-I) gene in the chum salmon (Oncorhynchus keta) genome. This gene, IGF-I.2, differs from the previously described chum salmon IGF-I gene, IGF-I.1, in the E peptide-coding portion of exon 3; specifically, the IGF-I.2 gene lacks one codon present in the IGF-I gene and contains two potential splice donor sites at the 3′ end of exon 3 rather than the single, more distal site present in the IGF-I.1 gene. The expression of these two IGF-I genes could give rise to as many as six IGF-I mRN A species, each of which would encode a unique E-peptide moiety of the IGF-I prohormone. Thus, the presence of multiple, distinct IGF genes adds an additional level of complexity to IGF-I gene expression and IGF-I biosynthesis in salmon.
AB - We have characterized a second nonallelic insulin-like growth factor-I (IGF-I) gene in the chum salmon (Oncorhynchus keta) genome. This gene, IGF-I.2, differs from the previously described chum salmon IGF-I gene, IGF-I.1, in the E peptide-coding portion of exon 3; specifically, the IGF-I.2 gene lacks one codon present in the IGF-I gene and contains two potential splice donor sites at the 3′ end of exon 3 rather than the single, more distal site present in the IGF-I.1 gene. The expression of these two IGF-I genes could give rise to as many as six IGF-I mRN A species, each of which would encode a unique E-peptide moiety of the IGF-I prohormone. Thus, the presence of multiple, distinct IGF genes adds an additional level of complexity to IGF-I gene expression and IGF-I biosynthesis in salmon.
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U2 - 10.1089/dna.1994.13.555
DO - 10.1089/dna.1994.13.555
M3 - Article
C2 - 8024699
AN - SCOPUS:0028037640
SN - 1044-5498
VL - 13
SP - 555
EP - 559
JO - DNA and Cell Biology
JF - DNA and Cell Biology
IS - 5
ER -