KHARON1 mediates flagellar targeting of a glucose transporter in Leishmania mexicana and is critical for viability of infectious intracellular amastigotes

Khoa D. Tran; Dayana Rodriguez-Contreras; Danielle P. Vieira; Phillip A. Yates; Larry David; Wandy Beatty; Johannes Elferich; Scott M. Landfear

doi:10.1074/jbc.M113.483461

KHARON1 mediates flagellar targeting of a glucose transporter in Leishmania mexicana and is critical for viability of infectious intracellular amastigotes

Khoa D. Tran, Dayana Rodriguez-Contreras, Danielle P. Vieira, Phillip A. Yates, Larry David, Wandy Beatty, Johannes Elferich, Scott M. Landfear

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Background: The mechanism for selectively targeting membrane proteins to the flagellum of kinetoplastid parasites is unknown. Results: We have identified a novel protein, KHARON1, which is important for the flagellar targeting of a glucose transporter. Conclusion: KHARON1 is the first protein identified in Kinetoplastida that targets a membrane protein to the flagellum. Significance: KHARON1 may be part of a new flagellar targeting pathway.

Original language	English (US)
Pages (from-to)	22721-22733
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	31
DOIs	https://doi.org/10.1074/jbc.M113.483461
State	Published - Aug 2 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Tran, K. D., Rodriguez-Contreras, D., Vieira, D. P., Yates, P. A., David, L., Beatty, W., Elferich, J., & Landfear, S. M. (2013). KHARON1 mediates flagellar targeting of a glucose transporter in Leishmania mexicana and is critical for viability of infectious intracellular amastigotes. Journal of Biological Chemistry, 288(31), 22721-22733. https://doi.org/10.1074/jbc.M113.483461

KHARON1 mediates flagellar targeting of a glucose transporter in Leishmania mexicana and is critical for viability of infectious intracellular amastigotes. / Tran, Khoa D.; Rodriguez-Contreras, Dayana; Vieira, Danielle P. et al.
In: Journal of Biological Chemistry, Vol. 288, No. 31, 02.08.2013, p. 22721-22733.

Research output: Contribution to journal › Article › peer-review

Tran, KD, Rodriguez-Contreras, D, Vieira, DP, Yates, PA , David, L, Beatty, W, Elferich, J & Landfear, SM 2013, 'KHARON1 mediates flagellar targeting of a glucose transporter in Leishmania mexicana and is critical for viability of infectious intracellular amastigotes', Journal of Biological Chemistry, vol. 288, no. 31, pp. 22721-22733. https://doi.org/10.1074/jbc.M113.483461

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abstract = "Background: The mechanism for selectively targeting membrane proteins to the flagellum of kinetoplastid parasites is unknown. Results: We have identified a novel protein, KHARON1, which is important for the flagellar targeting of a glucose transporter. Conclusion: KHARON1 is the first protein identified in Kinetoplastida that targets a membrane protein to the flagellum. Significance: KHARON1 may be part of a new flagellar targeting pathway.",

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AU - Vieira, Danielle P.

AU - Yates, Phillip A.

AU - David, Larry

AU - Beatty, Wandy

AU - Elferich, Johannes

AU - Landfear, Scott M.

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KHARON1 mediates flagellar targeting of a glucose transporter in Leishmania mexicana and is critical for viability of infectious intracellular amastigotes

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