TY - CHAP
T1 - Kisspeptin excitation of GnRH neurons
AU - Rønnekleiv, Oline K.
AU - Kelly, Martin J.
N1 - Funding Information:
The authors thank current and past members of their laboratories who contributed to the work described herein, especially Drs. Chunguang Zhang, Jian Qiu, Yuan Fang, Troy Roepke, and Ms. Martha A. Bosch; also, special thanks to Ms. Martha A. Bosch for her skilled assistance with the illustrations and manuscript preparations. The work from the authors’ laboratories was supported by NIH grants NS43330, NS38809, DK68098.
PY - 2013
Y1 - 2013
N2 - Kisspeptin binding to its cognate G protein-coupled receptor (GPR54, aka Kiss1R) in gonadotropin-releasing hormone (GnRH) neurons stimulates peptide release and activation of the reproductive axis in mammals. Kisspeptin has pronounced pre- and postsynaptic effects, with the latter dominating the excitability of GnRH neurons. Presynaptically, kisspeptin increases the excitatory drive (both GABA-A and glutamate) to GnRH neurons and postsynaptically, kisspeptin inhibits an A-type and inwardly rectifying K + (Kir 6.2 and GIRK) currents and activates nonselective cation (TRPC) currents to cause long-lasting depolarization and increased action potential firing. The signaling cascades and the multiple intracellular targets of kisspeptin actions in native GnRH neurons are continuing to be elucidated. This review summarizes our current state of knowledge about kisspeptin signaling in GnRH neurons.
AB - Kisspeptin binding to its cognate G protein-coupled receptor (GPR54, aka Kiss1R) in gonadotropin-releasing hormone (GnRH) neurons stimulates peptide release and activation of the reproductive axis in mammals. Kisspeptin has pronounced pre- and postsynaptic effects, with the latter dominating the excitability of GnRH neurons. Presynaptically, kisspeptin increases the excitatory drive (both GABA-A and glutamate) to GnRH neurons and postsynaptically, kisspeptin inhibits an A-type and inwardly rectifying K + (Kir 6.2 and GIRK) currents and activates nonselective cation (TRPC) currents to cause long-lasting depolarization and increased action potential firing. The signaling cascades and the multiple intracellular targets of kisspeptin actions in native GnRH neurons are continuing to be elucidated. This review summarizes our current state of knowledge about kisspeptin signaling in GnRH neurons.
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U2 - 10.1007/978-1-4614-6199-9_6
DO - 10.1007/978-1-4614-6199-9_6
M3 - Chapter
C2 - 23550004
AN - SCOPUS:84934435113
SN - 9781461461982
T3 - Advances in Experimental Medicine and Biology
SP - 113
EP - 131
BT - Kisspeptin Signaling in Reproductive Biology
PB - Springer New York LLC
ER -