Kisspeptin excitation of GnRH neurons

Oline K. Rønnekleiv; Martin J. Kelly

doi:10.1007/978-1-4614-6199-9_6

Kisspeptin excitation of GnRH neurons

Oline K. Rønnekleiv
, Martin J. Kelly

Research output: Chapter in Book/Report/Conference proceeding › Chapter

42 Scopus citations

Abstract

Kisspeptin binding to its cognate G protein-coupled receptor (GPR54, aka Kiss1R) in gonadotropin-releasing hormone (GnRH) neurons stimulates peptide release and activation of the reproductive axis in mammals. Kisspeptin has pronounced pre- and postsynaptic effects, with the latter dominating the excitability of GnRH neurons. Presynaptically, kisspeptin increases the excitatory drive (both GABA-A and glutamate) to GnRH neurons and postsynaptically, kisspeptin inhibits an A-type and inwardly rectifying K + (Kir 6.2 and GIRK) currents and activates nonselective cation (TRPC) currents to cause long-lasting depolarization and increased action potential firing. The signaling cascades and the multiple intracellular targets of kisspeptin actions in native GnRH neurons are continuing to be elucidated. This review summarizes our current state of knowledge about kisspeptin signaling in GnRH neurons.

Original language	English (US)
Title of host publication	Kisspeptin Signaling in Reproductive Biology
Publisher	Springer New York LLC
Pages	113-131
Number of pages	19
ISBN (Print)	9781461461982
DOIs	https://doi.org/10.1007/978-1-4614-6199-9_6
State	Published - 2013

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	784
ISSN (Print)	0065-2598

Funding

The authors thank current and past members of their laboratories who contributed to the work described herein, especially Drs. Chunguang Zhang, Jian Qiu, Yuan Fang, Troy Roepke, and Ms. Martha A. Bosch; also, special thanks to Ms. Martha A. Bosch for her skilled assistance with the illustrations and manuscript preparations. The work from the authors’ laboratories was supported by NIH grants NS43330, NS38809, DK68098.

Funders	Funder number
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health	NS43330, NS38809
National Institute of Diabetes and Digestive and Kidney Diseases	R01DK068098

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-1-4614-6199-9_6

Cite this

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title = "Kisspeptin excitation of GnRH neurons",

abstract = "Kisspeptin binding to its cognate G protein-coupled receptor (GPR54, aka Kiss1R) in gonadotropin-releasing hormone (GnRH) neurons stimulates peptide release and activation of the reproductive axis in mammals. Kisspeptin has pronounced pre- and postsynaptic effects, with the latter dominating the excitability of GnRH neurons. Presynaptically, kisspeptin increases the excitatory drive (both GABA-A and glutamate) to GnRH neurons and postsynaptically, kisspeptin inhibits an A-type and inwardly rectifying K + (Kir 6.2 and GIRK) currents and activates nonselective cation (TRPC) currents to cause long-lasting depolarization and increased action potential firing. The signaling cascades and the multiple intracellular targets of kisspeptin actions in native GnRH neurons are continuing to be elucidated. This review summarizes our current state of knowledge about kisspeptin signaling in GnRH neurons.",

author = "R{\o}nnekleiv, \{Oline K.\} and Kelly, \{Martin J.\}",

note = "Funding Information: The authors thank current and past members of their laboratories who contributed to the work described herein, especially Drs. Chunguang Zhang, Jian Qiu, Yuan Fang, Troy Roepke, and Ms. Martha A. Bosch; also, special thanks to Ms. Martha A. Bosch for her skilled assistance with the illustrations and manuscript preparations. The work from the authors{\textquoteright} laboratories was supported by NIH grants NS43330, NS38809, DK68098.",

year = "2013",

doi = "10.1007/978-1-4614-6199-9\_6",

language = "English (US)",

isbn = "9781461461982",

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PY - 2013

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N2 - Kisspeptin binding to its cognate G protein-coupled receptor (GPR54, aka Kiss1R) in gonadotropin-releasing hormone (GnRH) neurons stimulates peptide release and activation of the reproductive axis in mammals. Kisspeptin has pronounced pre- and postsynaptic effects, with the latter dominating the excitability of GnRH neurons. Presynaptically, kisspeptin increases the excitatory drive (both GABA-A and glutamate) to GnRH neurons and postsynaptically, kisspeptin inhibits an A-type and inwardly rectifying K + (Kir 6.2 and GIRK) currents and activates nonselective cation (TRPC) currents to cause long-lasting depolarization and increased action potential firing. The signaling cascades and the multiple intracellular targets of kisspeptin actions in native GnRH neurons are continuing to be elucidated. This review summarizes our current state of knowledge about kisspeptin signaling in GnRH neurons.

AB - Kisspeptin binding to its cognate G protein-coupled receptor (GPR54, aka Kiss1R) in gonadotropin-releasing hormone (GnRH) neurons stimulates peptide release and activation of the reproductive axis in mammals. Kisspeptin has pronounced pre- and postsynaptic effects, with the latter dominating the excitability of GnRH neurons. Presynaptically, kisspeptin increases the excitatory drive (both GABA-A and glutamate) to GnRH neurons and postsynaptically, kisspeptin inhibits an A-type and inwardly rectifying K + (Kir 6.2 and GIRK) currents and activates nonselective cation (TRPC) currents to cause long-lasting depolarization and increased action potential firing. The signaling cascades and the multiple intracellular targets of kisspeptin actions in native GnRH neurons are continuing to be elucidated. This review summarizes our current state of knowledge about kisspeptin signaling in GnRH neurons.

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ER -

Kisspeptin excitation of GnRH neurons

Abstract

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