Lack of correlation between coronary artery calcium and myocardial perfusion imaging

Jonathan Rosman, Michael Shapiro, Anuragini Pandey, Andrew VanTosh, Steven R. Bergmann

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Background: Coronary artery calcium (CAC) provides evidence of coronary atherosclerosis and has significant prognostic power. Although prior studies have documented a relationship between CAC and hemodynamically significant coronary artery stenosis, the results have not been conclusive. Methods and Results: We evaluated 126 consecutive patients who underwent electron beam computed tomography CAC scoring by use of the Agatston method and stress myocardial perfusion imaging (MPI) within 3 months of each other. The analysis revealed no correlation between absolute CAC score and age- and gender-adjusted CAC scores with MPI. Overall, 18% of patients had abnormal MPI results irrespective of their CAC. Conclusion: CAC scoring and stress MPI should be thus considered complementary approaches rather than exclusionary in the evaluation of the patient at risk for coronary artery disease.

Original languageEnglish (US)
Pages (from-to)333-337
Number of pages5
JournalJournal of Nuclear Cardiology
Issue number3
StatePublished - Jun 2006
Externally publishedYes


  • Myocardial perfusion imaging
  • atherosclerosis
  • coronary artery disease
  • single photon emission computed tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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