Lack of Functional Immunoregulatory Cells in a Patient With Mycosis Fungoides and Circulating Sezary Cells: Brief Communication

Vali Kermani-Arab; Janet L. Roberts; Jon M. Hanifin; Gerrie A. Leslie

doi:10.1093/jnci/60.6.1295

Lack of Functional Immunoregulatory Cells in a Patient With Mycosis Fungoides and Circulating Sezary Cells: Brief Communication

Vali Kermani-Arab
, Janet L. Roberts
, Jon M. Hanifin
, Gerrie A. Leslie

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Peripheral blood lymphocytes obtained at various intervals from normal individuals and from a patient with mycosis fungoides (MF) were cultured with phytohemagglutinin (PHA) for 3 days to activate suppressor cells. After being cultured, the PHA-treated cells were irradiated, washed, and then transferred to fresh medium with PHA. The PHA responsiveness of the cells from normal individuals was suppressed approximately 90% by autologous or normal allogeneic lymphocytes activated for 3 days with PHA, whereas the cells activated for 3 days with PHA from the patient with MF lacked the capacity to Inhibit the mitogenic response of autologous or allogeneic lymphocytes. These data suggest that this patient lacked suppressor T-cells that have a specificity for helper T-cells.-J Natl Cancer Inst 60: 1295-1299, 1978.

Original language	English (US)
Pages (from-to)	1295-1299
Number of pages	5
Journal	Journal of the National Cancer Institute
Volume	60
Issue number	6
DOIs	https://doi.org/10.1093/jnci/60.6.1295
State	Published - Jun 1978
Externally published	Yes

Funding

I Received August 12, 1977; accepted January 10, 1978. 2 Supported by the John A. Hartford Foundation, Inc. and the Veterans Administration Hospital of Portland. 3 Department of Microbiology and Immunology, University of Oregon Health Sciences Center, Ponland, Oreg. 9720 I . 4 Present address: Institute of Biochemistry and Biophysics, School of Public Health and Institute of Public Health Research, University of Teheran, Teheran, Iran. S N. L. Tartar Research Fellow at the University of Oregon Health Sciences Center. 6 Department of Dermatology, University of Oregon Health Sciences Center. 7 Address reprint requests to Dr. Leslie. 8 We.thank Dr. Marvin Cuchens, Mr. Douglas Dawson, and Ms. Joanie Olson (Department of Microbiology and Immunology) for their valuable comments; Dr. Robert Amon (Department of Dermatology) for the hematologic studies and blood samples; and Mr. Victor Richenstein (Department of Microbiology and Immunology) for excellent technical assistance.

Funders
John A. Hartford Foundation

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1093/jnci/60.6.1295

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@article{1d00e8df3e7e462c8aef57dafe52b56c,

title = "Lack of Functional Immunoregulatory Cells in a Patient With Mycosis Fungoides and Circulating Sezary Cells: Brief Communication",

abstract = "Peripheral blood lymphocytes obtained at various intervals from normal individuals and from a patient with mycosis fungoides (MF) were cultured with phytohemagglutinin (PHA) for 3 days to activate suppressor cells. After being cultured, the PHA-treated cells were irradiated, washed, and then transferred to fresh medium with PHA. The PHA responsiveness of the cells from normal individuals was suppressed approximately 90\% by autologous or normal allogeneic lymphocytes activated for 3 days with PHA, whereas the cells activated for 3 days with PHA from the patient with MF lacked the capacity to Inhibit the mitogenic response of autologous or allogeneic lymphocytes. These data suggest that this patient lacked suppressor T-cells that have a specificity for helper T-cells.-J Natl Cancer Inst 60: 1295-1299, 1978.",

author = "Vali Kermani-Arab and Roberts, \{Janet L.\} and Hanifin, \{Jon M.\} and Leslie, \{Gerrie A.\}",

note = "Funding Information: I Received August 12, 1977; accepted January 10, 1978. 2 Supported by the John A. Hartford Foundation, Inc. and the Veterans Administration Hospital of Portland. 3 Department of Microbiology and Immunology, University of Oregon Health Sciences Center, Ponland, Oreg. 9720 I . 4 Present address: Institute of Biochemistry and Biophysics, School of Public Health and Institute of Public Health Research, University of Teheran, Teheran, Iran. S N. L. Tartar Research Fellow at the University of Oregon Health Sciences Center. 6 Department of Dermatology, University of Oregon Health Sciences Center. 7 Address reprint requests to Dr. Leslie. 8 We.thank Dr. Marvin Cuchens, Mr. Douglas Dawson, and Ms. Joanie Olson (Department of Microbiology and Immunology) for their valuable comments; Dr. Robert Amon (Department of Dermatology) for the hematologic studies and blood samples; and Mr. Victor Richenstein (Department of Microbiology and Immunology) for excellent technical assistance.",

year = "1978",

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N2 - Peripheral blood lymphocytes obtained at various intervals from normal individuals and from a patient with mycosis fungoides (MF) were cultured with phytohemagglutinin (PHA) for 3 days to activate suppressor cells. After being cultured, the PHA-treated cells were irradiated, washed, and then transferred to fresh medium with PHA. The PHA responsiveness of the cells from normal individuals was suppressed approximately 90% by autologous or normal allogeneic lymphocytes activated for 3 days with PHA, whereas the cells activated for 3 days with PHA from the patient with MF lacked the capacity to Inhibit the mitogenic response of autologous or allogeneic lymphocytes. These data suggest that this patient lacked suppressor T-cells that have a specificity for helper T-cells.-J Natl Cancer Inst 60: 1295-1299, 1978.

AB - Peripheral blood lymphocytes obtained at various intervals from normal individuals and from a patient with mycosis fungoides (MF) were cultured with phytohemagglutinin (PHA) for 3 days to activate suppressor cells. After being cultured, the PHA-treated cells were irradiated, washed, and then transferred to fresh medium with PHA. The PHA responsiveness of the cells from normal individuals was suppressed approximately 90% by autologous or normal allogeneic lymphocytes activated for 3 days with PHA, whereas the cells activated for 3 days with PHA from the patient with MF lacked the capacity to Inhibit the mitogenic response of autologous or allogeneic lymphocytes. These data suggest that this patient lacked suppressor T-cells that have a specificity for helper T-cells.-J Natl Cancer Inst 60: 1295-1299, 1978.

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Lack of Functional Immunoregulatory Cells in a Patient With Mycosis Fungoides and Circulating Sezary Cells: Brief Communication

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