TY - JOUR
T1 - Laryngeal Papilloma
T2 - Etiologic and Therapeutic Considerations
AU - Cook, Ted A.
AU - Cohn, Arnold M.
AU - Brunschwig, J. Pierre
AU - Goepfert, Helmuth
AU - Butel, Janet S.
AU - Rawls, William E.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1973/9
Y1 - 1973/9
N2 - A study of 13 patients with laryngeal papillomas is presented, with an analysis of epidemiologic factors, electron microscopic study of the lesion, and therapeutic trial of frequent microlaryngoscopic surgery and application of idoxuridine. Five of the nine children in this group were delivered by mothers who had condyloma accuminatum at time of delivery. These five children developed symptoms and required surgery much earlier than the other four. This correlation is shown to be statistically significant. The electron microscopic study of tissue specimens from all our patients failed to find any actual virus particles. The comparison study with skin and genital warts, however, showed ultrastructural details linking the three lesions. Results of the therapeutic program showed an overall improvement in frequency of recurrence, but no complete cures. This improvement is felt to be related to frequent complete surgical excision, and not to application of idoxuridine.
AB - A study of 13 patients with laryngeal papillomas is presented, with an analysis of epidemiologic factors, electron microscopic study of the lesion, and therapeutic trial of frequent microlaryngoscopic surgery and application of idoxuridine. Five of the nine children in this group were delivered by mothers who had condyloma accuminatum at time of delivery. These five children developed symptoms and required surgery much earlier than the other four. This correlation is shown to be statistically significant. The electron microscopic study of tissue specimens from all our patients failed to find any actual virus particles. The comparison study with skin and genital warts, however, showed ultrastructural details linking the three lesions. Results of the therapeutic program showed an overall improvement in frequency of recurrence, but no complete cures. This improvement is felt to be related to frequent complete surgical excision, and not to application of idoxuridine.
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U2 - 10.1177/000348947308200507
DO - 10.1177/000348947308200507
M3 - Article
C2 - 4743394
AN - SCOPUS:0015909011
SN - 0003-4894
VL - 82
SP - 649
EP - 655
JO - Annals of Otology, Rhinology & Laryngology
JF - Annals of Otology, Rhinology & Laryngology
IS - 5
ER -