Late-Onset Alzheimer Disease

Aimee L. Pierce, Szofia S. Bullain, Claudia H. Kawas

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


The oldest-old represent the fastest growing segment of society, and the risk of developing dementia continues to increase with advancing age into the 9th and 10th decades of life. The most common form of dementia in the oldest-old is Alzheimer disease (AD), although there are often mixed pathologies contributing to dementia in addition to amyloid plaques and neurofibrillary tangles. Diagnosing AD in the oldest-old is challenging due to cognitive and physical changes associated with aging. Treatment remains supportive, with current approved medications able to provide modest symptomatic benefit but unable to slow the progression of disease.

Original languageEnglish (US)
Pages (from-to)283-293
Number of pages11
JournalNeurologic Clinics
Issue number2
StatePublished - May 2017
Externally publishedYes


  • Alzheimer disease
  • Dementia
  • Late-onset
  • Oldest-old
  • Pathology

ASJC Scopus subject areas

  • Clinical Neurology


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