TY - JOUR
T1 - Lathyrism in rural Northwestern Ethiopia
T2 - A highly prevalent neurotoxic disorder
AU - Haimanot, Redda Tekle
AU - Kidane, Yemane
AU - Wuhib, Elizabeth
AU - Kalissa, Angelina
AU - Alemu, Tadesse
AU - Zein, Zein Ahmed
AU - Spencer, Peter S.
N1 - Funding Information:
ACKNOWLEDGEMENTS These studies were made possible by the Third World Medical Research Foundation (TWMRF) with a grant from Band-Aid. Aregay Waktola, Principal Investigator of the Lathyrism Project in Ethiopia, Valerie Palmer of TWMRF and Penny Jenden of Band-Aid are thanked for their interest and support. Peter S Spencer was supported by grant NS19611 from the National Institutes of Health, Washington, DC, USA.
PY - 1990/9
Y1 - 1990/9
N2 - Haimanot R T (Faculty of Medicine, PO Box 4147, Addis Ababa University, Addis Ababa, Ethiopia), Kidane Y, Wuhib E, Kalissa A, Alemu T, Zein Z A and Spencer P S. Lathyrism in rural northwestern Ethiopia: A highly prevalent neurotoxic disorder. International Journal of Epidemiology 1990, 19: 664-672.Lathyrism is a disorder of the central motor system, induced by heavy consumption of the grass-pea, Lathyrus sativus an environmentally tolerant legume containing the neurotoxic excitatory amino acid beta-N-oxalylamino-L-alanine (BOAA). A complete door-to-door resurvey of the Dembia and Fogera regions of northwestern Ethiopia, areas endemic for lathyrism, revealed an estimated mean disease prevalence of 0.6%-2.9%. Most patients developed the disease in the epidemic of 1976/77, although new cases appear to have occurred with an estimated mean annual incidence of 1.7: 10 000. Production and consumption of grass-pea is increasing in Ethiopia, making attempts to develop low-BOAA strains to prevent lathyrism increasingly important.
AB - Haimanot R T (Faculty of Medicine, PO Box 4147, Addis Ababa University, Addis Ababa, Ethiopia), Kidane Y, Wuhib E, Kalissa A, Alemu T, Zein Z A and Spencer P S. Lathyrism in rural northwestern Ethiopia: A highly prevalent neurotoxic disorder. International Journal of Epidemiology 1990, 19: 664-672.Lathyrism is a disorder of the central motor system, induced by heavy consumption of the grass-pea, Lathyrus sativus an environmentally tolerant legume containing the neurotoxic excitatory amino acid beta-N-oxalylamino-L-alanine (BOAA). A complete door-to-door resurvey of the Dembia and Fogera regions of northwestern Ethiopia, areas endemic for lathyrism, revealed an estimated mean disease prevalence of 0.6%-2.9%. Most patients developed the disease in the epidemic of 1976/77, although new cases appear to have occurred with an estimated mean annual incidence of 1.7: 10 000. Production and consumption of grass-pea is increasing in Ethiopia, making attempts to develop low-BOAA strains to prevent lathyrism increasingly important.
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U2 - 10.1093/ije/19.3.664
DO - 10.1093/ije/19.3.664
M3 - Article
C2 - 2262262
AN - SCOPUS:0025197712
SN - 0300-5771
VL - 19
SP - 664
EP - 672
JO - International journal of epidemiology
JF - International journal of epidemiology
IS - 3
ER -