TY - JOUR
T1 - LCH‐I
T2 - A randomized trial of etoposide vs. vinblastine in disseminated langerhans cell histiocytosis
AU - Ladisch, Stephan
AU - Gadner, Helmut
AU - Arico, Maurizio
AU - Broadbent, Valerie
AU - Grois, Nicole
AU - Jacobson, Ake
AU - Komp, Diane
AU - Nicholson, H. Stacy
PY - 1994
Y1 - 1994
N2 - An international randomized trial in Langerhans cell histiocytosis (LCH) has been initiated by the Histiocyte Society. This report reviews the rationale, design, and progress of LCH‐I, which compares etoposide (VP‐16) and vinblastine in the treatment of disseminated LCH. Data on the risk of etoposide‐associated (therapy‐induced) malignancy, in the setting of histiocytosis, are reviewed. The available evidence leads to the recommendation that the study of etoposide in LCH should be continued. © 1994 Wiley‐Liss, Inc.
AB - An international randomized trial in Langerhans cell histiocytosis (LCH) has been initiated by the Histiocyte Society. This report reviews the rationale, design, and progress of LCH‐I, which compares etoposide (VP‐16) and vinblastine in the treatment of disseminated LCH. Data on the risk of etoposide‐associated (therapy‐induced) malignancy, in the setting of histiocytosis, are reviewed. The available evidence leads to the recommendation that the study of etoposide in LCH should be continued. © 1994 Wiley‐Liss, Inc.
KW - epipodophyllotoxin
KW - monocyte‐macrophage system
KW - secondary malignancies
UR - http://www.scopus.com/inward/record.url?scp=0028236278&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028236278&partnerID=8YFLogxK
U2 - 10.1002/mpo.2950230207
DO - 10.1002/mpo.2950230207
M3 - Article
C2 - 8202031
AN - SCOPUS:0028236278
SN - 1545-5009
VL - 23
SP - 107
EP - 110
JO - Medical and Pediatric Oncology
JF - Medical and Pediatric Oncology
IS - 2
ER -