TY - JOUR
T1 - Left and right ventricular diastolic function in adults with surgically repaired tetralogy of fallot
T2 - A multi-institutional study
AU - Aboulhosn, Jamil A.
AU - Lluri, Gentian
AU - Gurvitz, Michelle Z.
AU - Khairy, Paul
AU - Mongeon, François Pierre
AU - Kay, Joseph
AU - Valente, Anne Marie
AU - Earing, Michael G.
AU - Opotowsky, Alexander R.
AU - Lui, George
AU - Gersony, Deborah R.
AU - Cook, Stephen
AU - Child, John
AU - Ting, Jennifer
AU - Webb, Gary
AU - Landzberg, Michael
AU - Broberg, Craig S.
PY - 2013/7
Y1 - 2013/7
N2 - Background: Our purpose was to assess the prevalence and clinical implications of left ventricular (LV) and right ventricular (RV) diastolic dysfunction (DD) in patients with repaired tetralogy of Fallot (TOF). Methods: Adults with repaired TOF at 11 North American congenital heart disease centres were included. Of 556 patients analyzed, 325 had sufficient Doppler data to evaluate for LV DD, defined as mitral lateral e' < 10 cm/s and E/e' ratio ≥ 9. Abnormal RV diastolic function was defined as tricuspid E/A ratio of 0.8 to 2.1 with E/e' ratio ≥ 6 or a tricuspid ratio E/A ≥ 2.1 with a deceleration time < 120 milliseconds, and 105 patients were found to have sufficient Doppler data. Results: Abnormal LV diastolic Doppler indices were prevalent in 13.8% and associated with hypertension, dyslipidemia, 3 or more cardiac operations, and a history of ventricular tachycardia. Abnormal RV indices were prevalent in 52.4% and associated with hypertension, dyslipidemia, diabetes mellitus, and 3 or more cardiac operations. Ventricular tachycardia was more common in those with abnormal RV diastolic function. Conclusion: Further prospective studies are needed to evaluate these associations with DD and the impact of treatment risk factors on diastolic function and arrhythmia burden.
AB - Background: Our purpose was to assess the prevalence and clinical implications of left ventricular (LV) and right ventricular (RV) diastolic dysfunction (DD) in patients with repaired tetralogy of Fallot (TOF). Methods: Adults with repaired TOF at 11 North American congenital heart disease centres were included. Of 556 patients analyzed, 325 had sufficient Doppler data to evaluate for LV DD, defined as mitral lateral e' < 10 cm/s and E/e' ratio ≥ 9. Abnormal RV diastolic function was defined as tricuspid E/A ratio of 0.8 to 2.1 with E/e' ratio ≥ 6 or a tricuspid ratio E/A ≥ 2.1 with a deceleration time < 120 milliseconds, and 105 patients were found to have sufficient Doppler data. Results: Abnormal LV diastolic Doppler indices were prevalent in 13.8% and associated with hypertension, dyslipidemia, 3 or more cardiac operations, and a history of ventricular tachycardia. Abnormal RV indices were prevalent in 52.4% and associated with hypertension, dyslipidemia, diabetes mellitus, and 3 or more cardiac operations. Ventricular tachycardia was more common in those with abnormal RV diastolic function. Conclusion: Further prospective studies are needed to evaluate these associations with DD and the impact of treatment risk factors on diastolic function and arrhythmia burden.
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U2 - 10.1016/j.cjca.2012.11.003
DO - 10.1016/j.cjca.2012.11.003
M3 - Article
C2 - 23369488
AN - SCOPUS:84879498456
SN - 0828-282X
VL - 29
SP - 866
EP - 872
JO - Canadian Journal of Cardiology
JF - Canadian Journal of Cardiology
IS - 7
ER -