Leg Ulcers: Expanding the Differential

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Purpose of Review: Cutaneous lower extremity ulcerations are major source of morbidity and mortality. It can be challenging to identify an underlying etiology. This review provides a systematic framework for generating a thoughtful differential diagnosis and workup approach. We also highlight recent discoveries in the pathophysiology and treatment approaches of leg ulceration. Recent Findings: Venous leg ulceration is being treated with a number of promising new modalities including pentoxifylline, statin therapy, topical timolol, connexin-43 peptide antagonists, photodynamic therapy, and punch grafting. The role of vitamin K deficiency is gaining prominence with regard to calciphylaxis. Summary: Recognition of key risk factors and subtle physical exam findings can serve as clues to the underlying mechanism of cutaneous ulceration and direct a targeted workup for underlying systemic disease that may be ameliorated with appropriate therapy.

Original languageEnglish (US)
Pages (from-to)180-189
Number of pages10
JournalCurrent Dermatology Reports
Issue number3
StatePublished - Sep 1 2018


  • Calciphylaxis
  • Leg ulcer
  • Livedoid vasculopathy
  • Pyoderma gangrenosum
  • Venous ulcer

ASJC Scopus subject areas

  • Dermatology


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