Lens cytoskeleton and transparency: A model

John I. Clark; H. Matsushima; L. L. David; J. M. Clark

doi:10.1038/eye.1999.116

Lens cytoskeleton and transparency: A model

John I. Clark, H. Matsushima, L. L. David, J. M. Clark

Chemical Physiology and Biochemistry

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

The function of the cytoskeleton in lens was first considered when cytoplasmic microtubules were observed in elongating fibre cells of the chick lens nearly 40 years ago.¹ Since that time, tubulin, actin, vimentin and intermediate filaments have been identified and found to function in mitosis, motility and cellular morphology during lens cell differentiation.^2-10 A role for the cytoskeleton in accommodation has been proposed^3,8,9 and modification of the cytoskeletal proteins has been observed in several cataract models.^4,11-21 Recently, a progressive increase in protein aggregation and lens opacification was found to correspond with the loss of cytoskeletal protein in the selenite model for cataract.²² In the present report a model is proposed for the role of tubulin, actin, vimentin, spectrin and the lens-specific filaments, filensin and CP49, in the establishment and maintenance of transparent lens cell structure.

Original language	English (US)
Pages (from-to)	417-424
Number of pages	8
Journal	Eye (Basingstoke)
Volume	13
Issue number	3
DOIs	https://doi.org/10.1038/eye.1999.116
State	Published - May 1999

Keywords

Cataract
Cytoskeleton
Lens
Opacity
Transparency

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

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10.1038/eye.1999.116

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title = "Lens cytoskeleton and transparency: A model",

abstract = "The function of the cytoskeleton in lens was first considered when cytoplasmic microtubules were observed in elongating fibre cells of the chick lens nearly 40 years ago.1 Since that time, tubulin, actin, vimentin and intermediate filaments have been identified and found to function in mitosis, motility and cellular morphology during lens cell differentiation.2-10 A role for the cytoskeleton in accommodation has been proposed3,8,9 and modification of the cytoskeletal proteins has been observed in several cataract models.4,11-21 Recently, a progressive increase in protein aggregation and lens opacification was found to correspond with the loss of cytoskeletal protein in the selenite model for cataract.22 In the present report a model is proposed for the role of tubulin, actin, vimentin, spectrin and the lens-specific filaments, filensin and CP49, in the establishment and maintenance of transparent lens cell structure.",

keywords = "Cataract, Cytoskeleton, Lens, Opacity, Transparency",

author = "Clark, {John I.} and H. Matsushima and David, {L. L.} and Clark, {J. M.}",

note = "Funding Information: We are grateful for the generous assistance of P. Muchowski, Dr T. Hiraoka, Dr R. Quinlan and Ms C. Ganders. Supported by E404542 from the NEI. Funding Information: Support was provided by grant #04542 from the National Eye Institute of NIH",

year = "1999",

month = may,

doi = "10.1038/eye.1999.116",

language = "English (US)",

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pages = "417--424",

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T2 - A model

AU - Clark, John I.

AU - Matsushima, H.

AU - David, L. L.

AU - Clark, J. M.

N1 - Funding Information: We are grateful for the generous assistance of P. Muchowski, Dr T. Hiraoka, Dr R. Quinlan and Ms C. Ganders. Supported by E404542 from the NEI. Funding Information: Support was provided by grant #04542 from the National Eye Institute of NIH

PY - 1999/5

Y1 - 1999/5

N2 - The function of the cytoskeleton in lens was first considered when cytoplasmic microtubules were observed in elongating fibre cells of the chick lens nearly 40 years ago.1 Since that time, tubulin, actin, vimentin and intermediate filaments have been identified and found to function in mitosis, motility and cellular morphology during lens cell differentiation.2-10 A role for the cytoskeleton in accommodation has been proposed3,8,9 and modification of the cytoskeletal proteins has been observed in several cataract models.4,11-21 Recently, a progressive increase in protein aggregation and lens opacification was found to correspond with the loss of cytoskeletal protein in the selenite model for cataract.22 In the present report a model is proposed for the role of tubulin, actin, vimentin, spectrin and the lens-specific filaments, filensin and CP49, in the establishment and maintenance of transparent lens cell structure.

AB - The function of the cytoskeleton in lens was first considered when cytoplasmic microtubules were observed in elongating fibre cells of the chick lens nearly 40 years ago.1 Since that time, tubulin, actin, vimentin and intermediate filaments have been identified and found to function in mitosis, motility and cellular morphology during lens cell differentiation.2-10 A role for the cytoskeleton in accommodation has been proposed3,8,9 and modification of the cytoskeletal proteins has been observed in several cataract models.4,11-21 Recently, a progressive increase in protein aggregation and lens opacification was found to correspond with the loss of cytoskeletal protein in the selenite model for cataract.22 In the present report a model is proposed for the role of tubulin, actin, vimentin, spectrin and the lens-specific filaments, filensin and CP49, in the establishment and maintenance of transparent lens cell structure.

KW - Cataract

KW - Cytoskeleton

KW - Lens

KW - Opacity

KW - Transparency

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Lens cytoskeleton and transparency: A model

Abstract

Keywords

ASJC Scopus subject areas

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