Levodopa

J. Aldred; J. G. Nutt

doi:10.1016/B978-0-12-374105-9.00340-3

Levodopa

J. Aldred, J. G. Nutt

Neurology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

Levodopa is a large neutral amino acid that is converted by striatal aromatic amino acid decarboxylase into dopamine, and greatly improves motor function in Parkinson's disease. Many factors converge to complicate the pharmacokinetics of levodopa. The knowledge of levodopa metabolism has lead to several different treatment strategies to prolong dopamine action in the central nervous system.

Original language	English (US)
Title of host publication	Encyclopedia of Movement Disorders
Publisher	Elsevier Inc.
Pages	132-137
Number of pages	6
ISBN (Electronic)	9780123741059
ISBN (Print)	9780123741011
DOIs	https://doi.org/10.1016/B978-0-12-374105-9.00340-3
State	Published - Jan 1 2010

Keywords

Absorption
Amino acid decarboxylase
Carbidopa
Entacapone
Half-life levodopa
Metabolism
Rasagiline
Selegiline
Tolcapone

ASJC Scopus subject areas

Medicine(all)
Neuroscience(all)

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10.1016/B978-0-12-374105-9.00340-3

Cite this

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title = "Levodopa",

abstract = "Levodopa is a large neutral amino acid that is converted by striatal aromatic amino acid decarboxylase into dopamine, and greatly improves motor function in Parkinson's disease. Many factors converge to complicate the pharmacokinetics of levodopa. The knowledge of levodopa metabolism has lead to several different treatment strategies to prolong dopamine action in the central nervous system.",

keywords = "Absorption, Amino acid decarboxylase, Carbidopa, Entacapone, Half-life levodopa, Metabolism, Rasagiline, Selegiline, Tolcapone",

author = "J. Aldred and Nutt, {J. G.}",

year = "2010",

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doi = "10.1016/B978-0-12-374105-9.00340-3",

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T1 - Levodopa

AU - Aldred, J.

AU - Nutt, J. G.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Levodopa is a large neutral amino acid that is converted by striatal aromatic amino acid decarboxylase into dopamine, and greatly improves motor function in Parkinson's disease. Many factors converge to complicate the pharmacokinetics of levodopa. The knowledge of levodopa metabolism has lead to several different treatment strategies to prolong dopamine action in the central nervous system.

AB - Levodopa is a large neutral amino acid that is converted by striatal aromatic amino acid decarboxylase into dopamine, and greatly improves motor function in Parkinson's disease. Many factors converge to complicate the pharmacokinetics of levodopa. The knowledge of levodopa metabolism has lead to several different treatment strategies to prolong dopamine action in the central nervous system.

KW - Absorption

KW - Amino acid decarboxylase

KW - Carbidopa

KW - Entacapone

KW - Half-life levodopa

KW - Metabolism

KW - Rasagiline

KW - Selegiline

KW - Tolcapone

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U2 - 10.1016/B978-0-12-374105-9.00340-3

DO - 10.1016/B978-0-12-374105-9.00340-3

M3 - Chapter

AN - SCOPUS:85069856660

SN - 9780123741011

SP - 132

EP - 137

BT - Encyclopedia of Movement Disorders

PB - Elsevier Inc.

ER -

Levodopa

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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