@inproceedings{28c913cab1eb48d182722bc726013704,
title = "Ligand-conjugated quantum dots for targeted drug delivery to nerve cells",
abstract = "Increased interest in nanoparticle quantum dots as fluorescent probes possessing extended photostability, multi-color capability, and surface-controllable properties has made apparent their promising potential for biological and therapeutic applications. As an approach towards surface-functionalized nanoparticle drug delivery, here we report the development of quantum dots (QDs) complexed with the small peptide hormone {\ss}NGF. Surface modification and composition of ligand-conjugated QDs were confirmed using atomic force microscopy. Bioactivity and visual localization of ligand-QD complexes was assayed in live cells. Despite known structural and chemical stringency of ligand-receptor activation, we provide evidence to support activation of cell-surface trkA membrane receptor channels and downstream modulation of neurite sprouting. This QD-based capability bears significance for development of surface-conjugated nanoparticle drug delivery.",
keywords = "AFM, Drug delivery, Ligand, Nanobiotechnology, Nanostructures, Neuron, Quantum dots, Receptor, Stimulation",
author = "Vu, {Tania Q.} and Ravikanth Maddipati and Blute, {Todd A.} and Nehilla, {Barrett J.} and Leora Nusblat and Desai, {Tejal A.}",
year = "2005",
doi = "10.1109/MMB.2005.1548410",
language = "English (US)",
isbn = "0780387112",
series = "2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology",
pages = "152--153",
booktitle = "2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology",
note = "2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology ; Conference date: 12-05-2005 Through 15-05-2005",
}