Lithium ratio in vitro: Familial patterns of illness

Frederic J. Sautter, Robert Hitzermann, James Griffin, David L. Garver

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Psychiatric illness in first-degree relatives of psychotic patients with low, intermediate, and high red blood cell (RBC) in vitro lithium ratio (LR) was investigated using the Schedule for Affective Disorders and Schizophrenia and DSM-III. Fewer schizophrenia spectrum disorders were found in the first-degree relatives of high and low LR probands as compared to intermediate LR probands; high LR psychotic probands had families with an increased frequency of depressive spectrum disorder. Alcohol dependence and abuse was particularly prominent in the first-degree relatives of the higher LR probands. High LR may identify a disease that does not belong to the familial-genetic disorders of the schizophrenic spectrum; this illness may bear a closer relationship to disorders of the depressive spectrum.

Original languageEnglish (US)
Pages (from-to)257-266
Number of pages10
JournalPsychiatry Research
Issue number3
StatePublished - Jul 1986
Externally publishedYes


  • Red blood cell lithium ratio
  • depressive spectrum
  • familial-genetic disorders
  • schizophrenic spectrum

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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