Abstract
The mechanisms of interaction between lobeline and the dopamine transporter (DAT) or the vesicular monoamine transporter (VMAT-2) are not clear. The goal of this study was to elucidate the effects of lobeline on these transporters in a cell system co-expressing the DAT and VMAT-2. Lobeline caused release of [3H]dopamine to a similar extent as reserpine (VMAT-2 inhibitor), but was less efficacious than methamphetamine or dopamine. Additionally, lobeline decreased the [3H]dopamine-releasing effects of methamphetamine, unlike reserpine which increased release by methamphetamine. These results suggest that lobeline has unique properties at the DAT and VMAT-2 which may make it useful as a pharmacotherapeutic to treat methamphetamine abuse.
Original language | English (US) |
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Pages (from-to) | 1411-1415 |
Number of pages | 5 |
Journal | Biochemical Pharmacology |
Volume | 75 |
Issue number | 6 |
DOIs | |
State | Published - Mar 15 2008 |
Keywords
- Dopamine
- Dopamine transporter
- Lobeline
- Methamphetamine
- Vesicular monoamine transporter
ASJC Scopus subject areas
- Biochemistry
- Pharmacology