@article{cfa56aed40264040aa11340d88e5995b,
title = "Local tissue interactions across the dorsal midline of the forebrain establish CNS laterality",
abstract = "The mechanisms that establish behavioral, cognitive, and neuroanatomical asymmetries are poorly understood. In this study, we analyze the events that regulate development of asymmetric nuclei in the dorsal forebrain. The unilateral parapineal organ has a bilateral origin, and some parapineal precursors migrate across the midline to form this left-sided nucleus. The parapineal subsequently innervates the left habenula, which derives from ventral epithalamic cells adjacent to the parapineal precursors. Ablation of cells in the left ventral epithalamus can reverse laterality in wild-type embryos and impose the direction of CNS asymmetry in embryos in which laterality is usually randomized. Unilateral modulation of Nodal activity by Lefty1 can also impose the direction of CNS laterality in embryos with bilateral expression of Nodal pathway genes. From these data, we propose that laterality is determined by a competitive interaction between the left and right epithalamus and that Nodal signaling biases the outcome of this competition.",
author = "Concha, {Miguel L.} and Claire Russell and Regan, {Jennifer C.} and Marcel Tawk and Samuel Sidi and Gilmour, {Darren T.} and Marika Kapsimali and Lauro Sumoy and Kim Goldstone and Enrique Amaya and David Kimelman and Teresa Nicolson and Stefan Gr{\"u}nder and Miranda Gomperts and Clarke, {Jonathan D.W.} and Wilson, {Stephen W.}",
note = "Funding Information: We thank Alex Schier for valuable suggestions for experiments; members of our groups for discussion of the project; Carole Wilson and her team for care of the fish; and Marnie Halpern for communication of results prior to publication. This work was supported by grants from the Wellcome Trust, Biotechnology and Biological Sciences Research Council, and European Community (to S.W.W.); support from the Wellcome Trust, Fondecyt (1020902), and Fundaci{\'o}n Andes (C-13760) (to M.L.C.); from the Wellcome Trust (to M.G. and E.A.); and from the Attempto Research Group program (to S.G.). M.T. and J.D.W.C. are supported by the Medical Research Council. S.W.W. is a Wellcome Trust Senior Research Fellow, and M.L.C. is a Wellcome Trust International Research Development Award Fellow.",
year = "2003",
month = jul,
day = "31",
doi = "10.1016/S0896-6273(03)00437-9",
language = "English (US)",
volume = "39",
pages = "423--438",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "3",
}