Localization of a human brain sodium channel gene (SCN2A) to chromosome 2

M. Litt; J. Luty; M. Kwak; L. Allen; R. E. Magenis; G. Mandel

doi:10.1016/0888-7543(89)90047-5

Localization of a human brain sodium channel gene (SCN2A) to chromosome 2

M. Litt, J. Luty, M. Kwak, L. Allen, R. E. Magenis, G. Mandel

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

A DNA probe derived from a human genomic library has been used to localize on human chromosomes a gene coding for the α-subunit of the brain type II sodium channel (SCN2A). Hybridization of the probe to Southern blots made with DNAs from a rodent-human somatic cell hybrid panel indicates localization to the long arm of human chromosome 2. In situ hybridization to metaphase chromosomes confirms this assignment and indicates regional localization to 2q21-q33. The probe also reveals a frequent two-allele HaeIII RFLP.

Original language	English (US)
Pages (from-to)	204-208
Number of pages	5
Journal	Genomics
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/0888-7543(89)90047-5
State	Published - Aug 1989
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1016/0888-7543(89)90047-5

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title = "Localization of a human brain sodium channel gene (SCN2A) to chromosome 2",

abstract = "A DNA probe derived from a human genomic library has been used to localize on human chromosomes a gene coding for the α-subunit of the brain type II sodium channel (SCN2A). Hybridization of the probe to Southern blots made with DNAs from a rodent-human somatic cell hybrid panel indicates localization to the long arm of human chromosome 2. In situ hybridization to metaphase chromosomes confirms this assignment and indicates regional localization to 2q21-q33. The probe also reveals a frequent two-allele HaeIII RFLP.",

author = "M. Litt and J. Luty and M. Kwak and L. Allen and Magenis, {R. E.} and G. Mandel",

note = "Funding Information: Excellent technical assistance was provided by Ruth Litt. We thank Gail Brims for providing the somatic cell hybrid mapping panel. This work was supported by NIH Grants ROl-GM32500 (to M.L.) and ROl-NS22518 (to G.M.), by Maternal and Child Health Grant MCT 920 (to R.E.M.), and by a grant from the Retinitis Pigmentosa Foundation Fighting Blindness (to M.L.).",

year = "1989",

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doi = "10.1016/0888-7543(89)90047-5",

language = "English (US)",

volume = "5",

pages = "204--208",

journal = "Genomics",

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T1 - Localization of a human brain sodium channel gene (SCN2A) to chromosome 2

AU - Litt, M.

AU - Luty, J.

AU - Kwak, M.

AU - Allen, L.

AU - Magenis, R. E.

AU - Mandel, G.

N1 - Funding Information: Excellent technical assistance was provided by Ruth Litt. We thank Gail Brims for providing the somatic cell hybrid mapping panel. This work was supported by NIH Grants ROl-GM32500 (to M.L.) and ROl-NS22518 (to G.M.), by Maternal and Child Health Grant MCT 920 (to R.E.M.), and by a grant from the Retinitis Pigmentosa Foundation Fighting Blindness (to M.L.).

PY - 1989/8

Y1 - 1989/8

N2 - A DNA probe derived from a human genomic library has been used to localize on human chromosomes a gene coding for the α-subunit of the brain type II sodium channel (SCN2A). Hybridization of the probe to Southern blots made with DNAs from a rodent-human somatic cell hybrid panel indicates localization to the long arm of human chromosome 2. In situ hybridization to metaphase chromosomes confirms this assignment and indicates regional localization to 2q21-q33. The probe also reveals a frequent two-allele HaeIII RFLP.

AB - A DNA probe derived from a human genomic library has been used to localize on human chromosomes a gene coding for the α-subunit of the brain type II sodium channel (SCN2A). Hybridization of the probe to Southern blots made with DNAs from a rodent-human somatic cell hybrid panel indicates localization to the long arm of human chromosome 2. In situ hybridization to metaphase chromosomes confirms this assignment and indicates regional localization to 2q21-q33. The probe also reveals a frequent two-allele HaeIII RFLP.

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Localization of a human brain sodium channel gene (SCN2A) to chromosome 2

Abstract

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