Localization of a human brain sodium channel gene (SCN2A) to chromosome 2

M. Litt; J. Luty; M. Kwak; L. Allen; R. E. Magenis; G. Mandel

doi:10.1016/0888-7543(89)90047-5

Localization of a human brain sodium channel gene (SCN2A) to chromosome 2

M. Litt
, J. Luty
, M. Kwak
, L. Allen
, R. E. Magenis
, G. Mandel

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

A DNA probe derived from a human genomic library has been used to localize on human chromosomes a gene coding for the α-subunit of the brain type II sodium channel (SCN2A). Hybridization of the probe to Southern blots made with DNAs from a rodent-human somatic cell hybrid panel indicates localization to the long arm of human chromosome 2. In situ hybridization to metaphase chromosomes confirms this assignment and indicates regional localization to 2q21-q33. The probe also reveals a frequent two-allele HaeIII RFLP.

Original language	English (US)
Pages (from-to)	204-208
Number of pages	5
Journal	Genomics
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/0888-7543(89)90047-5
State	Published - Aug 1989
Externally published	Yes

Funding

Excellent technical assistance was provided by Ruth Litt. We thank Gail Brims for providing the somatic cell hybrid mapping panel. This work was supported by NIH Grants ROl-GM32500 (to M.L.) and ROl-NS22518 (to G.M.), by Maternal and Child Health Grant MCT 920 (to R.E.M.), and by a grant from the Retinitis Pigmentosa Foundation Fighting Blindness (to M.L.).

Funders	Funder number
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health	ROl-GM32500
National Institute of Neurological Disorders and Stroke	R01NS022518
Foundation Fighting Blindness
Maternal and Child Health Research Program , Maternal and Child Health Bureau	MCT 920

ASJC Scopus subject areas

Genetics

Access to Document

10.1016/0888-7543(89)90047-5

Cite this

@article{67c931e030624a72ba37a1a2fbaac5d5,

title = "Localization of a human brain sodium channel gene (SCN2A) to chromosome 2",

abstract = "A DNA probe derived from a human genomic library has been used to localize on human chromosomes a gene coding for the α-subunit of the brain type II sodium channel (SCN2A). Hybridization of the probe to Southern blots made with DNAs from a rodent-human somatic cell hybrid panel indicates localization to the long arm of human chromosome 2. In situ hybridization to metaphase chromosomes confirms this assignment and indicates regional localization to 2q21-q33. The probe also reveals a frequent two-allele HaeIII RFLP.",

author = "M. Litt and J. Luty and M. Kwak and L. Allen and Magenis, \{R. E.\} and G. Mandel",

note = "Funding Information: Excellent technical assistance was provided by Ruth Litt. We thank Gail Brims for providing the somatic cell hybrid mapping panel. This work was supported by NIH Grants ROl-GM32500 (to M.L.) and ROl-NS22518 (to G.M.), by Maternal and Child Health Grant MCT 920 (to R.E.M.), and by a grant from the Retinitis Pigmentosa Foundation Fighting Blindness (to M.L.).",

year = "1989",

month = aug,

doi = "10.1016/0888-7543(89)90047-5",

language = "English (US)",

volume = "5",

pages = "204--208",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Localization of a human brain sodium channel gene (SCN2A) to chromosome 2

AU - Litt, M.

AU - Luty, J.

AU - Kwak, M.

AU - Allen, L.

AU - Magenis, R. E.

AU - Mandel, G.

N1 - Funding Information: Excellent technical assistance was provided by Ruth Litt. We thank Gail Brims for providing the somatic cell hybrid mapping panel. This work was supported by NIH Grants ROl-GM32500 (to M.L.) and ROl-NS22518 (to G.M.), by Maternal and Child Health Grant MCT 920 (to R.E.M.), and by a grant from the Retinitis Pigmentosa Foundation Fighting Blindness (to M.L.).

PY - 1989/8

Y1 - 1989/8

N2 - A DNA probe derived from a human genomic library has been used to localize on human chromosomes a gene coding for the α-subunit of the brain type II sodium channel (SCN2A). Hybridization of the probe to Southern blots made with DNAs from a rodent-human somatic cell hybrid panel indicates localization to the long arm of human chromosome 2. In situ hybridization to metaphase chromosomes confirms this assignment and indicates regional localization to 2q21-q33. The probe also reveals a frequent two-allele HaeIII RFLP.

AB - A DNA probe derived from a human genomic library has been used to localize on human chromosomes a gene coding for the α-subunit of the brain type II sodium channel (SCN2A). Hybridization of the probe to Southern blots made with DNAs from a rodent-human somatic cell hybrid panel indicates localization to the long arm of human chromosome 2. In situ hybridization to metaphase chromosomes confirms this assignment and indicates regional localization to 2q21-q33. The probe also reveals a frequent two-allele HaeIII RFLP.

UR - https://www.scopus.com/pages/publications/0024710681

UR - https://www.scopus.com/pages/publications/0024710681#tab=citedBy

U2 - 10.1016/0888-7543(89)90047-5

DO - 10.1016/0888-7543(89)90047-5

M3 - Article

C2 - 2571571

AN - SCOPUS:0024710681

SN - 0888-7543

VL - 5

SP - 204

EP - 208

JO - Genomics

JF - Genomics

IS - 2

ER -

Localization of a human brain sodium channel gene (SCN2A) to chromosome 2

Abstract

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this