@article{b4175b03ad224665a8e2c6771352a8a1,
title = "Localization of 125I-insulin binding sites in the rat hypothalamus by quantitative autoradiography",
abstract = "In vitro autoradiography and computer video densitometry were used to localize and quantify binding of 125I-insulin in the hypothalamus of the rat brain. Highest specific binding was found in the arcuate. dorsomedial, suprachiasmatic, paraventricular and periventricular regions. Significantly lower binding was present in the ventromedial nucleus and median eminence. The results are consistent with the hypothesis that insulin modulates the neural regulation of feeding by acting at sites in the hypothalamus.",
keywords = "Autoradiography, Brain, Feeding, Insulin, Rat, Receptor",
author = "Corp, {Eric S.} and Woods, {Stephen C.} and Daniel Porte and Dorsa, {Daniel M.} and Figlewicz, {Dianne P.} and Baskin, {Denis G.}",
note = "Funding Information: This work was supported by NIH Grant AM 17047 to the Diabetes Research Center, University of Washington, NIH Grants AM 17844, AM 12829 and NS 2031 l, University of Washington Graduate School Research Grants, NCI Grant CA 33996, and by the Veterans Administration. D.P.F. was the recipient of an American Diabetes Association Career Development Award and a Pilot and Feasibility Grant with thc University of Washington Clinical Nutrition Unit. We thank Dr. Thomas Paquette for the labeled insulin and the Lilly Corporation for the unlabeled insulin.",
year = "1986",
month = sep,
day = "25",
doi = "10.1016/0304-3940(86)90430-1",
language = "English (US)",
volume = "70",
pages = "17--22",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",
}