Localization of the fibrillin (FBN) gene to chromosome 15, band q21.1

R. Ellen Magenis, Cheryl L. Maslen, Leslie Smith, Leland Allen, Lynn Y. Sakai

Research output: Contribution to journalArticlepeer-review

120 Scopus citations

Abstract

Fibrillin (FBN), a large extracellular matrix glycoprotein, is an important component of structures called microfibrils. Because fibrillin microfibrils appear to be abnormal in patients with the Marfan syndrome, fibrillin is a candidate for the gene defect in the Marfan syndrome. Derived clones from fibrillin cDNA were used as probes in isotopic and nonisotopic in situ hybridization studies to map the chromosomal location of the fibrillin gene. Fluorescent signals were found on chromosome 15 band q21.1; an excess of silver grains was noted over a similar region of chromosome 15 following in situ hybridization with a tritium-labeled probe. These results are consistent with linkage studies that localize the Marfan gene to chromosome 15.

Original languageEnglish (US)
Pages (from-to)346-351
Number of pages6
JournalGenomics
Volume11
Issue number2
DOIs
StatePublished - Oct 1991

ASJC Scopus subject areas

  • Genetics

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