Localization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum

James O. Deshler, Martin I. Highett, Bruce J. Schnapp

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


In many organisms, pattern formation in the embryo develops from the polarized distributions of messenger RNAs (mRNAs) in the egg. In Xenopus, the mRNA encoding Vg1, a growth factor involved in mesoderm induction, is localized to the vegetal cortex of oocytes. A protein named Vera was shown to be involved in Vg1 mRNA localization. Vera cofractionates with endoplasmic reticulum (ER) membranes, and endogenous Vg1 mRNA is associated with a subcompartment of the ER. Vera may promote mRNA localization in Xenopus oocytes by mediating an interaction between the Vg1 3' untranslated region and the ER subcompartment.

Original languageEnglish (US)
Pages (from-to)1128-1131
Number of pages4
Issue number5315
StatePublished - May 16 1997
Externally publishedYes

ASJC Scopus subject areas

  • General


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