Localization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum

James O. Deshler; Martin I. Highett; Bruce J. Schnapp

doi:10.1126/science.276.5315.1128

Localization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum

James O. Deshler, Martin I. Highett, Bruce J. Schnapp

Research output: Contribution to journal › Article › peer-review

237 Scopus citations

Abstract

In many organisms, pattern formation in the embryo develops from the polarized distributions of messenger RNAs (mRNAs) in the egg. In Xenopus, the mRNA encoding Vg1, a growth factor involved in mesoderm induction, is localized to the vegetal cortex of oocytes. A protein named Vera was shown to be involved in Vg1 mRNA localization. Vera cofractionates with endoplasmic reticulum (ER) membranes, and endogenous Vg1 mRNA is associated with a subcompartment of the ER. Vera may promote mRNA localization in Xenopus oocytes by mediating an interaction between the Vg1 3' untranslated region and the ER subcompartment.

Original language	English (US)
Pages (from-to)	1128-1131
Number of pages	4
Journal	Science
Volume	276
Issue number	5315
DOIs	https://doi.org/10.1126/science.276.5315.1128
State	Published - May 16 1997
Externally published	Yes

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title = "Localization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum",

abstract = "In many organisms, pattern formation in the embryo develops from the polarized distributions of messenger RNAs (mRNAs) in the egg. In Xenopus, the mRNA encoding Vg1, a growth factor involved in mesoderm induction, is localized to the vegetal cortex of oocytes. A protein named Vera was shown to be involved in Vg1 mRNA localization. Vera cofractionates with endoplasmic reticulum (ER) membranes, and endogenous Vg1 mRNA is associated with a subcompartment of the ER. Vera may promote mRNA localization in Xenopus oocytes by mediating an interaction between the Vg1 3' untranslated region and the ER subcompartment.",

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AU - Highett, Martin I.

AU - Schnapp, Bruce J.

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N2 - In many organisms, pattern formation in the embryo develops from the polarized distributions of messenger RNAs (mRNAs) in the egg. In Xenopus, the mRNA encoding Vg1, a growth factor involved in mesoderm induction, is localized to the vegetal cortex of oocytes. A protein named Vera was shown to be involved in Vg1 mRNA localization. Vera cofractionates with endoplasmic reticulum (ER) membranes, and endogenous Vg1 mRNA is associated with a subcompartment of the ER. Vera may promote mRNA localization in Xenopus oocytes by mediating an interaction between the Vg1 3' untranslated region and the ER subcompartment.

AB - In many organisms, pattern formation in the embryo develops from the polarized distributions of messenger RNAs (mRNAs) in the egg. In Xenopus, the mRNA encoding Vg1, a growth factor involved in mesoderm induction, is localized to the vegetal cortex of oocytes. A protein named Vera was shown to be involved in Vg1 mRNA localization. Vera cofractionates with endoplasmic reticulum (ER) membranes, and endogenous Vg1 mRNA is associated with a subcompartment of the ER. Vera may promote mRNA localization in Xenopus oocytes by mediating an interaction between the Vg1 3' untranslated region and the ER subcompartment.

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Localization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum

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