Long-term humoral immunity against viruses: Revisiting the issue of plasma cell longevity

Mark K. Slifka; Rafi Ahmed

doi:10.1016/0966-842X(96)10059-7

Long-term humoral immunity against viruses: Revisiting the issue of plasma cell longevity

Mark K. Slifka, Rafi Ahmed

Research output: Contribution to journal › Review article › peer-review

87 Scopus citations

Abstract

Despite extensive documentation of prolonged antibody responses following vaccination or acute viral infection, the mechanisms behind long-term antibody production are not fully understood. We propose the hypothesis that long-lived plasma cells are an important, yet largely overlooked, component of long-term humoral immunity.

Original language	English (US)
Pages (from-to)	394-400
Number of pages	7
Journal	Trends in microbiology
Volume	4
Issue number	10
DOIs	https://doi.org/10.1016/0966-842X(96)10059-7
State	Published - Oct 1996
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Virology
Infectious Diseases

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10.1016/0966-842X(96)10059-7

Cite this

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title = "Long-term humoral immunity against viruses: Revisiting the issue of plasma cell longevity",

abstract = "Despite extensive documentation of prolonged antibody responses following vaccination or acute viral infection, the mechanisms behind long-term antibody production are not fully understood. We propose the hypothesis that long-lived plasma cells are an important, yet largely overlooked, component of long-term humoral immunity.",

author = "Slifka, {Mark K.} and Rafi Ahmed",

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N2 - Despite extensive documentation of prolonged antibody responses following vaccination or acute viral infection, the mechanisms behind long-term antibody production are not fully understood. We propose the hypothesis that long-lived plasma cells are an important, yet largely overlooked, component of long-term humoral immunity.

AB - Despite extensive documentation of prolonged antibody responses following vaccination or acute viral infection, the mechanisms behind long-term antibody production are not fully understood. We propose the hypothesis that long-lived plasma cells are an important, yet largely overlooked, component of long-term humoral immunity.

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Long-term humoral immunity against viruses: Revisiting the issue of plasma cell longevity

Abstract

ASJC Scopus subject areas

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