Abstract
The effects of the muscarinic agonist carbachol and the D2 dopaminergic agonist quinpirole on phosphoinositide hydrolysis were studied in the corpus striatum of rats which had been treated for one year with either haloperidol or clozapine. In the presence of LiCl, carbachol increased the accumulation of inositol monophosphate (/s>100%) and bisposphate (/s>20%). Quinpirole had no effect on either basal or carbachol-stimulated accumulation of inositol phosphates. There was no difference in these responses between the drug-treated animals and age-matched controls.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 385-388 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 496 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Sep 4 1989 |
| Externally published | Yes |
Funding
This work was supported by USPHS Grants Kll MH-00747 (to J.E.R.), MH-41440 and MH-00378 (to R.Y.W.), and MH-43385 and V.A. Res. Serv. (to R.J.H.). We thank Deyuan Jiang for her technical assistancew ith animal care and gratefully acknowledge the donations of haloperidol, clozapine and quinpirole from McNeil, Sandoz and Eli Lilly, respectively.
| Funders | Funder number |
|---|---|
| National Institutes of Health National Institute of Mental Health | K11MH000747 |
| U.S. Public Health Service | MH-00378, MH-43385, MH-00747, MH-41440 |
Keywords
- Antipsychotic drug
- Chronic drug treatment
- Clozapine
- D dopamine receptor
- Haloperidol
- Inositol phosphate
- Muscarinic receptor
- Rat striatum
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology
Fingerprint
Dive into the research topics of 'Long-term treatment with antipsychotics does not alter the phosphoinositide response to muscarinic or D2 dopaminergic agonists in rat striatum'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS