TY - JOUR
T1 - Longer-term Safety of B-Cell Therapy with Ocrelizumab in Multiple Sclerosis
AU - Yeh, E. Ann
AU - Bourdette, Dennis
AU - Wiendl, Heinz
N1 - Publisher Copyright:
© 2021 American Academy of Neurology.
PY - 2021/10/19
Y1 - 2021/10/19
N2 - Treatment options in multiple sclerosis (MS) have expanded tremendously, with 23 disease-modifying therapies (DMT) approved in the United States since 1993. Along with the increasing number of approved MS DMTs, refinements to diagnostic criteria and recognition of the benefits of early treatment have led clinicians to diagnose and treat patients when they have a first demyelinating episode. Furthermore, treatment approaches have shifted to the use of more powerful, highly efficacious agents, including monoclonal antibodies (mAbs), at onset.1 The newer therapies, such as natalizumab, alemtuzumab, and the anti-B-cell mAb ocrelizumab, have made "no evidence of disease activity"a realistic therapeutic target, delayed the onset of progressive disease, and led to improved quality of life of individuals with MS. Yet these agents are a double-edged sword: with higher efficacy comes potential risks, particularly with long-term use of these therapies.2
AB - Treatment options in multiple sclerosis (MS) have expanded tremendously, with 23 disease-modifying therapies (DMT) approved in the United States since 1993. Along with the increasing number of approved MS DMTs, refinements to diagnostic criteria and recognition of the benefits of early treatment have led clinicians to diagnose and treat patients when they have a first demyelinating episode. Furthermore, treatment approaches have shifted to the use of more powerful, highly efficacious agents, including monoclonal antibodies (mAbs), at onset.1 The newer therapies, such as natalizumab, alemtuzumab, and the anti-B-cell mAb ocrelizumab, have made "no evidence of disease activity"a realistic therapeutic target, delayed the onset of progressive disease, and led to improved quality of life of individuals with MS. Yet these agents are a double-edged sword: with higher efficacy comes potential risks, particularly with long-term use of these therapies.2
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U2 - 10.1212/WNL.0000000000012716
DO - 10.1212/WNL.0000000000012716
M3 - Editorial
C2 - 34475129
AN - SCOPUS:85117731164
SN - 0028-3878
VL - 97
SP - 751
EP - 753
JO - Neurology
JF - Neurology
IS - 16
ER -