TY - JOUR
T1 - Longitudinal Study of New Eye Lesions in Children with Toxoplasmosis Who Were Not Treated During the First Year of Life
AU - Phan, Laura
AU - Kasza, Kristen
AU - Jalbrzikowski, Jessica
AU - Noble, A. Gwendolyn
AU - Latkany, Paul
AU - Kuo, Annie
AU - Mieler, William
AU - Meyers, Sanford
AU - Rabiah, Peter
AU - Boyer, Kenneth
AU - Swisher, Charles
AU - Mets, Marilyn
AU - Roizen, Nancy
AU - Cezar, Simone
AU - Sautter, Mari
AU - Remington, Jack
AU - Meier, Paul
AU - Mcleod, Rima
N1 - Funding Information:
This study was supported in part by the NIH (RO1 NIAID AI 1-27530-15), Bethesda, Maryland and the Research to Prevent Blindness Foundation, New York, New York; the Hyatt Hotel Foundation, Chicago, Illinois; United Airlines Friendly Skies, Braniff International Airways, Southwest Airlines, American Airlines, Air Canada, and Angel Flight America; and the Langel, Morel, Kiewit, Rooney-Alden, Blackman, Rosenstein, Kapnick, Cussen, Samuel, Taub, and Singer families. The authors indicate no financial conflict of interest. Involved in design of study (S.M., K.B., C.S., M.M., N.R., P.M., R.M.); conduct of study (W.M., P.R., K.B., S.C., J.R., P.M., M.S., R.M.); collection, management, analysis, and interpretation of the data (L.P., K.K., J.J., A.G.N., P.L., A.K., W.M., S.M., P.R., K.B., C.S., M.M., N.R., S.C., J.R., P.M., M.S., R.M.); and preparation, review, or approval of manuscript (L.P., K.K., J.J., A.G.N., P.L., W.M., S.M., P.R., C.S., M.M., N.R., S.C., M.S., R.M.). Institutional Review Board (IRB) approval was obtained at the University of Chicago for this study. Written informed consent was obtained from all parents or legal guardians of participating minor-age children and/or directly from the patient (if of legal adult age). This study also is in compliance with all Health Insurance Portability and Accountability Act of 1996 (HIPAA) regulations. Because this cohort study deals with only historical patients, those who were not treated during the first year of life, this study does not qualify as a clinical trial.
PY - 2008/9
Y1 - 2008/9
N2 - Purpose: To determine the incidence of new chorioretinal lesions in children with toxoplasmosis diagnosed after, and therefore not treated during, their first year. Design: Prospective longitudinal cohort study. Methods: Thirty-eight children were evaluated in Chicago between 1981 and 2005 for new chorioretinal lesions. Thirty-eight children and mothers had serum IgG antibody to Toxoplasma gondii. Results: Twenty-eight of 38 children had one of the following: diagnosis with serum antibody to T. gondii indicative of chronic infection at age 24 months, central nervous system calcifications, hydrocephalus, illness compatible with congenital toxoplasmosis perinatally but not diagnosed at that time. Twenty-five returned for follow-up during 1981 to 2005. Their mean (range) age at last exam was 10.9 ± 5.7 (range, 3.5 to 27.2) years and mean follow-up was 5.7 ± 2.9 years. Eighteen (72%) children developed at least one new lesion. Thirteen (52%) had new central lesions, 11 (44%) had new peripheral lesions, and six (24%) had both. Thirteen (52%) had new lesions diagnosed at age ≥10 years. New lesions were found at more than one visit in four (22%), and bilateral new lesions developed in seven (39%) of 18 children who developed new lesions. Of 10 additional children with eye findings and serologic tests indicative of chronic infection, six returned for follow-up, four (67%) developing new lesions at ≥10 years of age. Conclusions: More than 70% developed new chorioretinal lesions. New lesions were commonly diagnosed after the first decade of life.
AB - Purpose: To determine the incidence of new chorioretinal lesions in children with toxoplasmosis diagnosed after, and therefore not treated during, their first year. Design: Prospective longitudinal cohort study. Methods: Thirty-eight children were evaluated in Chicago between 1981 and 2005 for new chorioretinal lesions. Thirty-eight children and mothers had serum IgG antibody to Toxoplasma gondii. Results: Twenty-eight of 38 children had one of the following: diagnosis with serum antibody to T. gondii indicative of chronic infection at age 24 months, central nervous system calcifications, hydrocephalus, illness compatible with congenital toxoplasmosis perinatally but not diagnosed at that time. Twenty-five returned for follow-up during 1981 to 2005. Their mean (range) age at last exam was 10.9 ± 5.7 (range, 3.5 to 27.2) years and mean follow-up was 5.7 ± 2.9 years. Eighteen (72%) children developed at least one new lesion. Thirteen (52%) had new central lesions, 11 (44%) had new peripheral lesions, and six (24%) had both. Thirteen (52%) had new lesions diagnosed at age ≥10 years. New lesions were found at more than one visit in four (22%), and bilateral new lesions developed in seven (39%) of 18 children who developed new lesions. Of 10 additional children with eye findings and serologic tests indicative of chronic infection, six returned for follow-up, four (67%) developing new lesions at ≥10 years of age. Conclusions: More than 70% developed new chorioretinal lesions. New lesions were commonly diagnosed after the first decade of life.
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U2 - 10.1016/j.ajo.2008.04.033
DO - 10.1016/j.ajo.2008.04.033
M3 - Article
C2 - 18619570
AN - SCOPUS:49749134702
SN - 0002-9394
VL - 146
SP - 375-384.e4
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 3
ER -