Lost in Translation? Finding Our Way to Effective Alzheimer's Disease Therapies

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Efforts over the past two decades to develop effective disease-modifying treatments for Alzheimer's disease have been disappointing, while parallel efforts in another chronic neurologic disease, multiple sclerosis, have been remarkably productive. In an effort to advance development of therapeutics for Alzheimer's disease, these two fields are contrasted in terms of the utility of animal models, definition of study populations, and utility of biomarkers. Possible solutions are suggested, and the review concludes with description of some active peer-reviewed, publicly funded clinical studies which address some of the identified weaknesses in past clinical trials for age-related dementia.

Original languageEnglish (US)
Pages (from-to)S33-S39
JournalJournal of Alzheimer's Disease
Issue numbers1
StatePublished - 2018


  • Alzheimer's disease
  • animal models
  • clinical trials

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


Dive into the research topics of 'Lost in Translation? Finding Our Way to Effective Alzheimer's Disease Therapies'. Together they form a unique fingerprint.

Cite this