Low intracellular iron increases the stability of Matriptase-2

Ningning Zhao; Christopher P. Nizzi; Sheila A. Anderson; Jiaohong Wang; Akiko Ueno; Hidekazu Tsukamoto; Richard S. Eisenstein; Caroline A. Enns; An Sheng Zhang

doi:10.1074/jbc.M114.611913

Low intracellular iron increases the stability of Matriptase-2

Ningning Zhao, Christopher P. Nizzi, Sheila A. Anderson, Jiaohong Wang, Akiko Ueno, Hidekazu Tsukamoto, Richard S. Eisenstein, Caroline A. Enns, An Sheng Zhang

Cell Developmental and Cancer Biology

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Background: Matriptase-2 (MT2) is essential for iron homeostasis. The mechanism for its regulation is controversial. Results: The cytoplasmic domain of MT2 is necessary for its stabilization by iron depletion. MT2 expression is not regulated at either the transcriptional mRNA or translational level by iron. Conclusion: Depletion of cellular iron stabilizes MT2. Significance: Low iron levels in hepatocytes stabilize MT2 to suppress hepcidin expression.

Original language	English (US)
Pages (from-to)	4432-4446
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	290
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M114.611913
State	Published - Feb 13 2015

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M114.611913

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title = "Low intracellular iron increases the stability of Matriptase-2",

abstract = "Background: Matriptase-2 (MT2) is essential for iron homeostasis. The mechanism for its regulation is controversial. Results: The cytoplasmic domain of MT2 is necessary for its stabilization by iron depletion. MT2 expression is not regulated at either the transcriptional mRNA or translational level by iron. Conclusion: Depletion of cellular iron stabilizes MT2. Significance: Low iron levels in hepatocytes stabilize MT2 to suppress hepcidin expression.",

author = "Ningning Zhao and Nizzi, {Christopher P.} and Anderson, {Sheila A.} and Jiaohong Wang and Akiko Ueno and Hidekazu Tsukamoto and Eisenstein, {Richard S.} and Enns, {Caroline A.} and Zhang, {An Sheng}",

note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.",

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doi = "10.1074/jbc.M114.611913",

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T1 - Low intracellular iron increases the stability of Matriptase-2

AU - Zhao, Ningning

AU - Nizzi, Christopher P.

AU - Anderson, Sheila A.

AU - Wang, Jiaohong

AU - Ueno, Akiko

AU - Tsukamoto, Hidekazu

AU - Eisenstein, Richard S.

AU - Enns, Caroline A.

AU - Zhang, An Sheng

PY - 2015/2/13

Y1 - 2015/2/13

N2 - Background: Matriptase-2 (MT2) is essential for iron homeostasis. The mechanism for its regulation is controversial. Results: The cytoplasmic domain of MT2 is necessary for its stabilization by iron depletion. MT2 expression is not regulated at either the transcriptional mRNA or translational level by iron. Conclusion: Depletion of cellular iron stabilizes MT2. Significance: Low iron levels in hepatocytes stabilize MT2 to suppress hepcidin expression.

AB - Background: Matriptase-2 (MT2) is essential for iron homeostasis. The mechanism for its regulation is controversial. Results: The cytoplasmic domain of MT2 is necessary for its stabilization by iron depletion. MT2 expression is not regulated at either the transcriptional mRNA or translational level by iron. Conclusion: Depletion of cellular iron stabilizes MT2. Significance: Low iron levels in hepatocytes stabilize MT2 to suppress hepcidin expression.

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SP - 4432

EP - 4446

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

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Low intracellular iron increases the stability of Matriptase-2

Abstract

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