Lymphoma of the nasal cavity and paranasal sinuses: A case series

Toby O. Steele, Maria C. Buniel, Jess C. Mace, Edward El Rassi, Timothy L. Smith

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Background: Lymphomas of the sinonasal tract are a rare and heterogeneous subset of solid sinonasal neoplasms. Objective: To characterize, in this case series, presenting symptoms, treatment modalities, and outcomes for patients with sinonas ymphoma with n a single institution. Methods: Retrospective patient data were collected from an academic, oncologic center and entered into a repository designed to capture outcomes for sinonasal malignancies. Patient demographics, presenting symptoms, imaging findings, treatment modalities, and health status were retrospectively extrapolated and evaluated by using Kaplan-Meier estimations for survival probability. Results: Patients with sinonasal lymphoma with a mean follow-up of 50 months were identified (n =). Histologic nosis included the following: diffuse large B-cell lymphoma (n = 9), natural killer/T-cell lymphoma (n = 5), follicular lymphoma (n = 1), T-cell lymphoma (n = 1), and lymphoma-not otherwise specified (n = 2). The most frequent presenting symptoms were nasal obstruction (78%), facial pain (72%), al swelling (50%), and nasal discharge (44%). Treatment before lymphoma diagnosis included antibiotics (83%), oral steroids (22%), decongestants (22%), and topical steroids (11%). Treatment regimens after diagnosis included both chemotherapy (94%) and chemoradiotherapy (56%). Survival rates by lymphoma subtype were 56% for B-cell lymphoma and 40% for natural killer/T-cell lymphoma. Overall, 2- and 5-year survival rates were 67% and 50%, respectively. The combination of chemotherapy and radiation resulted in significantly higher survival rates (p ≥ 0.001) than emotherapy ne. Conclusion: Sinonasal lymphomas are characterized by meager survival rates, which differ by histopathologic subtype. The diagnosis of sinonasal lymphoma is challenging because symptoms frequently parallel those of chronic rhinosinusitis. Increased awareness of these rare malignancies may improve detection and more timely treatment. Clinical trial registration NCT01332136.

Original languageEnglish (US)
Pages (from-to)335-339
Number of pages5
JournalAmerican Journal of Rhinology and Allergy
Issue number5
StatePublished - Sep 1 2016

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology


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