Malignant hyperthermia of anesthesia

Bruce M. Wolfe, L. W. Gaston, R. M. Keltner

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Malignant hyperthermia of anesthesia generally occurs in otherwise healthy subjects and carries a high mortality. It is characterized by rapid elevation in body temperature, muscular rigidity, ventricular arrhythmias, acidosis, and cardiovascular collapse. Successful management is dependent on immediate diagnosis, discontinuation of anesthesia, hyperventilation, cooling, and appropriate drugs. Several cases of hemorrhage secondary to disseminated intravascular coagulation have been reported, and routine heparinization is recommended while appropriate laboratory studies are carried out. Two cases of malignant hyperthermia of anesthesia are reported. In the first case diffuse hemorrhage secondary to disseminated intravascular coagulation played a significant role in the patient's death. In the second case prompt therapeutic maneuvers, including the use of procaine, led to eventual recovery.

Original languageEnglish (US)
Pages (from-to)717-721
Number of pages5
JournalThe American Journal of Surgery
Issue number6
StatePublished - Dec 1973

ASJC Scopus subject areas

  • Surgery


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