TY - JOUR
T1 - Malignant melanoma and vitiligo-like leukoderma
T2 - An electron microscopic study
AU - Koh, Howard K.
AU - Sober, Arthur J.
AU - Nakagawa, Hidemi
AU - Albert, Daniel M.
AU - Mihm, Martin C.
AU - Fitzpatrick, Thomas B.
N1 - Funding Information:
Supported in part by the National Cancer InstituteG rant No. R l0 CA 13651-01 CCI, the Marion Gardner Jackson Trust and National Institutes of Health Training Grant No. 5 T32 AM 07098.
PY - 1983
Y1 - 1983
N2 - We report clinical and ultrastructural results in eight patients with melanoma and widespread leukoderma. Leukoderma appears to be a good prognostic sign. Although some features of this entity are suggestive of vitiligo, the patients' age, the distribution and appearance of body lesions, and ultrastructural results show a more varied clinical and ultrastructural spectrum. The high frequency of ocular pigmentary disturbances and uveitis in this patient population is noteworthy and deserves further study. We would recommend routine use of Wood's light examination in following patients with thick stage I, stage II, or stage III melanoma to facilitate detection of this phenomenon.
AB - We report clinical and ultrastructural results in eight patients with melanoma and widespread leukoderma. Leukoderma appears to be a good prognostic sign. Although some features of this entity are suggestive of vitiligo, the patients' age, the distribution and appearance of body lesions, and ultrastructural results show a more varied clinical and ultrastructural spectrum. The high frequency of ocular pigmentary disturbances and uveitis in this patient population is noteworthy and deserves further study. We would recommend routine use of Wood's light examination in following patients with thick stage I, stage II, or stage III melanoma to facilitate detection of this phenomenon.
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U2 - 10.1016/S0190-9622(83)70183-0
DO - 10.1016/S0190-9622(83)70183-0
M3 - Article
C2 - 6643768
AN - SCOPUS:0021081554
SN - 0190-9622
VL - 9
SP - 696
EP - 708
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 5
ER -