Malignant melanoma and vitiligo-like leukoderma: An electron microscopic study

Howard K. Koh, Arthur J. Sober, Hidemi Nakagawa, Daniel M. Albert, Martin C. Mihm, Thomas B. Fitzpatrick

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


We report clinical and ultrastructural results in eight patients with melanoma and widespread leukoderma. Leukoderma appears to be a good prognostic sign. Although some features of this entity are suggestive of vitiligo, the patients' age, the distribution and appearance of body lesions, and ultrastructural results show a more varied clinical and ultrastructural spectrum. The high frequency of ocular pigmentary disturbances and uveitis in this patient population is noteworthy and deserves further study. We would recommend routine use of Wood's light examination in following patients with thick stage I, stage II, or stage III melanoma to facilitate detection of this phenomenon.

Original languageEnglish (US)
Pages (from-to)696-708
Number of pages13
JournalJournal of the American Academy of Dermatology
Issue number5
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


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