Malignant transformation of an optic pathway glioma without prior radiation therapy

Garrett K. Zoeller, Carole D. Brathwaite, David I. Sandberg

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Optic pathway gliomas (OPGs) arise from the optic nerves, optic chiasm, and/or hypothalamus and most commonly occur in childhood. Although these tumors can be quite challenging to manage, they are typically low-grade astrocytomas histologically, most commonly pilocytic astrocytomas. The few previously reported cases of malignant degeneration of an OPG occurred after external beam radiation therapy. The authors report the first case in the English literature of an OPG that transformed from a low-grade astrocytoma, with features most consistent with a pilocytic astrocytoma, to a malignant glioma without any exposure to radiation therapy.

Original languageEnglish (US)
Pages (from-to)507-510
Number of pages4
JournalJournal of Neurosurgery: Pediatrics
Issue number5
StatePublished - May 2010
Externally publishedYes


  • Glioblastoma multiforme
  • Malignant transformation
  • Optic pathway glioma
  • Pilocytic astrocytoma
  • Radiation therapy

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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