TY - JOUR
T1 - Mammalian bombesin-like peptides
AU - Spindel, Eliot
N1 - Funding Information:
I wish to thank William W. Chin for his many suggestionsR. esearchfrom the author'sla boratoryw as supportedb y the Howard HughesM edicalI nstitutea nd by NIH Grant No. R23-CA39237.
PY - 1986
Y1 - 1986
N2 - Mammalian bombesin-like peptides share structural homology with the large family of amphibian bombesin-like peptides. At present there is evidence for two classes of mammalian bombesin-like peptides, the gastrin-releasing peptides (GRP) and the ranatensin-like peptides. GRPs are distributed throughout the mammalian central nervous system, peripheral nervous system, gastrointestinal (GI) tract and the lung where they act as neurotransmitters, autocrine hormones and growth factors. Less is known about the ranatensin-like peptides which to date have been detected only in the brain and spinal cord. The large number of amphibian bombesin-like peptides suggests that still more mammalian bombesin-like peptides remain to be characterized. The challenge will be to determine the key physiological roles of the entire family of these peptides.
AB - Mammalian bombesin-like peptides share structural homology with the large family of amphibian bombesin-like peptides. At present there is evidence for two classes of mammalian bombesin-like peptides, the gastrin-releasing peptides (GRP) and the ranatensin-like peptides. GRPs are distributed throughout the mammalian central nervous system, peripheral nervous system, gastrointestinal (GI) tract and the lung where they act as neurotransmitters, autocrine hormones and growth factors. Less is known about the ranatensin-like peptides which to date have been detected only in the brain and spinal cord. The large number of amphibian bombesin-like peptides suggests that still more mammalian bombesin-like peptides remain to be characterized. The challenge will be to determine the key physiological roles of the entire family of these peptides.
UR - http://www.scopus.com/inward/record.url?scp=0022633004&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022633004&partnerID=8YFLogxK
U2 - 10.1016/0166-2236(86)90042-1
DO - 10.1016/0166-2236(86)90042-1
M3 - Review article
AN - SCOPUS:0022633004
SN - 0166-2236
VL - 9
SP - 130
EP - 133
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - C
ER -