Management of bleeding with uremia and liver disease

Bleeding can complicate the clinical course of both liver disease and uremia. The pathogenesis of bleeding in both syndromes is complex. A variety of options are available for treatment of uremic bleeding including desmopressin, erythropoietin, and estrogens. Bleeding complications of liver disease reflect the importance of this organ for the production of both coagulation factors and thrombopoietin. Careful assessment of both the patient's clinical situation and laboratory findings is important for tailoring therapy of the bleeding patient. (C) 1999 Lippincott Williams and Wilkins, Inc.