Management of peripheral neuropathic pain

Brett R. Stacey

Research output: Contribution to journalReview articlepeer-review

82 Scopus citations


Neuropathic pain results from a variety of medical conditions encountered in physiatric practice, including infection, trauma, metabolic abnormalities, and nerve compression. Unlike pain resulting from nociceptive or inflammatory processes, neuropathic pain is associated with primary lesion or dysfunction of the nervous system itself and is often difficult to treat. Existing treatment options include drug therapy (e.g., anticonvulsants, the lidocaine patch 5%, antidepressants, opioids, tramadol) or interventional treatments (e.g., peripheral or neuraxial nerve blockade, implanted spinal cord stimulators, implanted intrathecal catheters). The following article presents an overview of the cellular mechanisms associated with neuropathic pain, summarizes the results of randomized, controlled trials with the major classes of available drugs, and discusses treatment options that provide a rational basis for pharmacotherapy.

Original languageEnglish (US)
Pages (from-to)S4-S16
JournalAmerican Journal of Physical Medicine and Rehabilitation
Issue number3 SUPPL.
StatePublished - Mar 2005


  • Central Sensitization
  • Chronic Pain
  • Clinical Trials
  • Diabetic Peripheral Neuropathy
  • Double-Blind
  • Literature Review
  • Mechanisms
  • Neuropathic Pain
  • Peripheral Sensitization
  • Pharmacotherapy
  • Postherpetic Neuralgia
  • Randomized
  • Treatment

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation


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