Massive strychnine intoxication: Serial blood levels in a fatal case

John M. Heiser, Mohamud R. Daya, A. Roy Magnussen, Robert L. Norton, Daniel A. Spyker, David W. Allen, Wendell Krasselt

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


A fatal case of strychnine intoxication is reported. The patient expired despite early aggressive management and prevention of metabolic complications. Serial blood levels are reported. In contrast to a previous report describing first order elimination kinetics, our data suggest that strychnine follows Michaelis-Menton elimination kinetics. The case illustrates the rapid, dramatic course of severe strychnine ingestions. A review of the toxicokinetics, mechanism of action and treatment of strychnine intoxication follows.

Original languageEnglish (US)
Pages (from-to)269-283
Number of pages15
JournalClinical Toxicology
Issue number2
StatePublished - 1992


  • Pharmacokinetics
  • Poisoning, human
  • Review
  • Strychnine

ASJC Scopus subject areas

  • Toxicology


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